지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.1
- 수록면
- 357 - 370 (14page)
이용수
초록· 키워드
오류제보하기
Radiation therapy, the most commonly used for the treatment of brain tumors, has been shown to be of major significance in tumor control and survival rate of brain tumor patients. About 200,000 patients with brain tumor are treated with either partial large field or whole brain radiation every year in the United States. The use of radiation therapy for treatment of brain tumors, however, may lead to devastating functional deficits in brain several months to years after treatment. In particular, whole brain radiation therapy results in a significant reduction in learning and memory in brain tumor patients as long-term consequences of treatment. Although a number of in vitro and in vivo studies have demonstrated the pathogenesis of radiation-mediated brain injury, the cellular and molecular mechanisms by which radiation induces damage to normal tissue in brain remain largely unknown. Therefore, this review focuses on the pathophysiological mechanisms of whole brain radiation-induced cognitive impairment and the identification of novel therapeutic targets. Specifically, we review the current knowledge about the effects of whole brain radiation on pro-oxidative and pro-inflammatory pathways, matrix metalloproteinases (MMPs)/tissue inhibitors of metalloproteinases (TIMPs) system and extracellular matrix (ECM), and physiological angiogenesis in brain. These studies may provide a foundation for defining a new cellular and molecular basis related to the etiology of cognitive impairment that occurs among patients in response to whole brain radiation therapy. It may also lead to new opportunities for therapeutic interventions for brain tumor patients who are undergoing whole brain radiation therapy.
목차
등록된 정보가 없습니다.
참고문헌 (193)
참고문헌 신청
Abbott, N. J. / 2006 / Astrocyte-endothelial interactions at the blood-brain barrier / Nat. Rev. Neurosci 7:41~53
Abou-Seif, M. A. / 2003 / Amelioration of radiation-induced oxidative stress and biochemical alteration by SOD model compounds in pre-treated gamma-irradiated rats / Clin. Chim. Acta 337:23~33
Acharya, M. M. / 2009 / Rescue of radiation-induced cognitive impairment through cranial transplantation of human embryonic stem cells / Proc. Natl. Acad. Sci. USA 106:19150~19155
Acharya, M. M. / 2011 / Human neural stem cell transplantation ameliorates radiation-induced cognitive dysfunction / Cancer Res 71:4834~4845
Acharya, M. M. / 2010 / Consequences of ionizing radiation-induced damage in human neural stem cells / Free Radic. Biol. Med 49:1846~1855
Abou-Seif, M. A. / 2003 / Amelioration of radiation-induced oxidative stress and biochemical alteration by SOD model compounds in pre-treated gamma-irradiated rats / Clin. Chim. Acta 337:23~33
Acharya, M. M. / 2009 / Rescue of radiation-induced cognitive impairment through cranial transplantation of human embryonic stem cells / Proc. Natl. Acad. Sci. USA 106:19150~19155
Acharya, M. M. / 2011 / Human neural stem cell transplantation ameliorates radiation-induced cognitive dysfunction / Cancer Res 71:4834~4845
Acharya, M. M. / 2010 / Consequences of ionizing radiation-induced damage in human neural stem cells / Free Radic. Biol. Med 49:1846~1855
이 논문의 저자 정보
최근 본 자료
댓글(0)
0