지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.1
- 수록면
- 57 - 61 (5page)
이용수
초록· 키워드
오류제보하기
The matrix metalloproteinase (MMP) family is involved in the breakdown of the extracellular matrix during normal physiological processes such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes such as pathological aging, arthritis, and metastasis. Oxidative conditions generate reactive oxygen species (ROS) (e.g., hydrogen peroxide [$H_2O_2$]) in cells, which subsequently induce the synthesis of matrix metalloproteinase-1 (MMP-1). MMP-1, an interstitial collagenase, in turn stimulates an aging phenomenon. In this study, baicalein (5,6,7-trihydroxyfl avone) was investigated for its in vitro activity against $H_2O_2$-induced damage using a human skin keratinocyte model. Baicalein pretreatment signifi cantly inhibited $H_2O_2$-induced up-regulation of MMP-1 mRNA, MMP-1 protein expression and MMP-1 activity in cultured HaCaT keratinocytes. In addition, baicalein decreased the transcriptional activity of activator protein-1 (AP-1) and the expression of c-Fos and c-Jun, both components of the heterodimeric AP-1 transcription factor. Furthermore, baicalein reduced phosphorylation of extracellular signal-regulated kinase (ERK) and c-Jun-N-terminal kinase (JNK), which are upstream of the AP-1 transcription factor. The results of this study suggest that baicalein is involved in the inhibition of oxidative stress-induced expression of MMP-1 via inactivation of the ERK/JNK/AP-1 signaling pathway.
목차
등록된 정보가 없습니다.
참고문헌 (30)
참고문헌 신청
Bogoyevitch, M. A. / 2010 / c-Jun N-terminal kinase (JNK) signaling: recent advances and challenges / Biochim. Biophys. Acta 1804:463~475
Brenneisen, P. / 1997 / Hydrogen peroxide (H2O2) increases the steady-state mRNA levels of collagenase/MMP-1 in human dermal fi broblasts / Free. Radic. Biol. Med 22:515~524
Brenneisen, P. / 2002 / Ultraviolet- B irradiation and matrix metalloproteinases: from induction via signaling to initial events / Ann. N. Y. Acad. Sci 973:31~43
Cano, E. / 1994 / Anisomycinactivated protein kinases p45 and p55 but not mitogen-activated protein kinases ERK-1 and -2 are implicated in the induction of c-fos and c-jun / Mol. Cell. Biol 14:7352~7362
Cho, Y. H. / 2006 / Inhibitory effects of antioxidant constituents from Melothria heterophylla on matrix metalloproteinase-1 expression in UVAirradiated human dermal fi broblasts / J. Cosmet. Sci 57:279~289
Brenneisen, P. / 1997 / Hydrogen peroxide (H2O2) increases the steady-state mRNA levels of collagenase/MMP-1 in human dermal fi broblasts / Free. Radic. Biol. Med 22:515~524
Brenneisen, P. / 2002 / Ultraviolet- B irradiation and matrix metalloproteinases: from induction via signaling to initial events / Ann. N. Y. Acad. Sci 973:31~43
Cano, E. / 1994 / Anisomycinactivated protein kinases p45 and p55 but not mitogen-activated protein kinases ERK-1 and -2 are implicated in the induction of c-fos and c-jun / Mol. Cell. Biol 14:7352~7362
Cho, Y. H. / 2006 / Inhibitory effects of antioxidant constituents from Melothria heterophylla on matrix metalloproteinase-1 expression in UVAirradiated human dermal fi broblasts / J. Cosmet. Sci 57:279~289
이 논문의 저자 정보
최근 본 자료
댓글(0)
0