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학제간연구 과학기술학 뇌인지과학 기술정책 기타 복합학

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논문 기본 정보

자료유형
학술저널
저자정보
Cho, Tack Geun (Department of Neurosurgery, Hallym University Kangnam Sacred Heart Hospital, Hallym University College of Medicine) Park, Seung Won (Department of Neurosurgery, Chung-Ang University Hospital, Chung-Ang University College of Medicine) Kim, Young Baeg (Department of Neurosurgery, Chung-Ang University Hospital, Chung-Ang University College of Medicine)
저널정보
대한신경외과학회 대한신경외과학회지 대한신경외과학회지 제59권 제5호
발행연도
2016.1
수록면
430 - 436 (7page)

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Objective : The objective of this study is to establish an animal model of chronic paraspinal muscle injury in rat. Methods : Fifty four Sprague-Dawley male rats were divided into experimental group (n=30), sham (n=15), and normal group (n=9). Incision was done from T7 to L2 and paraspinal muscles were detached from spine and tied at each level. The paraspinal muscles were exposed and untied at 2 weeks after surgery. Sham operation was done by paraspinal muscles dissection at the same levels and wound closure was done without tying. Kyphotic index and thoracolumbar Cobb's angle were measured at preoperative, 2, 4, 8, and 12 weeks after the first surgery for all groups. The rats were sacrificed at 4, 8, and 12 weeks after the first surgery, and performed histological examinations. Results : At 4 weeks after surgery, the kyphotic index decreased, but, Cobb's angle increased significantly in the experimental group (p<0.05), and then that were maintained until the end of the experiment. However, there were no significant differences of the kyphotic index and Cobb's angle between sham and normal groups. In histological examinations, necrosis and fibrosis were observed definitely and persisted until 12 weeks after surgery. There were also presences of regenerated muscle cells which nucleus is at the center of cytoplasm, centronucleated myofibers. Conclusion : Our chronic injury model of paraspinal muscles in rats shows necrosis and fibrosis in the muscles for 12 weeks after surgery, which might be useful to study the pathophysiology of the degenerative thoracolumbar kyphosis or degeneration of paraspinal muscles.
#Animal model #Paraspinal muscle #Chronic injury #Kyphosis #Degeneration

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참고문헌 (25)

참고문헌 신청
Ball JM / 2009 / Spinal extension exercises prevent natural progression of kyphosis / Osteoporos Int 20:481~489 google schola Booth KC / 1999 / Complications and predictive factors for the successful treatment of flatback deformity (fixed sagittal imbalance) / Spine 24:1712~1720 google schola Brereton D / 2012 / The effects of glucocorticoid and voluntary exercise treatment on the development of thoracolumbar kyphosis in dystrophin-deficient mice / PLoS Curr 4:e4ffdff160 google schola Bridwell KH / 2001 / Treatment of spinal stenosis and fixed sagittal imbalance / Clin Orthop Relat Res 384:35~44 google schola Cabukoglu C / 2004 / Effect of sagittal plane deformity of the lumbar spine on epidural fibrosis formation after laminectomy : an experimental study in the rat / Spine 29:2242~2247 google schola

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