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논문 기본 정보

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학술저널
저자정보
Lee, Sang-Il (Departent of Food, Nutrition and Culinary Arts, Keimyung College) Kim, Jae-Won (Faculty of Food Science and Industrial Technology, Catholic University of Daegu) Lee, Ye-Kyung (Division of Bioscience and Bioinformatics, College of Natural Science, Myongji University) Yang, Seung-Hwan (Division of Bioscience and Bioinformatics, College of Natural Science, Myongji University) Lee, In-Ae (Division of Bioscience and Bioinformatics, College of Natural Science, Myongji University) Suh, Joo-Won (Division of Bioscience and Bioinformatics, College of Natural Science, Myongji University) Kim, Soon-Dong (Division of Bioscience and Bioinformatics, College of Natural Science, Myongji University)
저널정보
한국응용생명화학회 Journal of applied biological chemistry Journal of applied biological chemistry 제54권 제3호
발행연도
2011.1
수록면
197 - 205 (9page)

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This study was carried out to investigate the dietary effects of Monascus pilosus mycelial extract on obesity in high-fat with cholesterol-induced obese rat models. It was observed that M. pilosus mycelial extract contains $25.85{\pm}1.98mg%$ of total monacolin K without citrinin by highperformance liquid chromatography (HPLC). The rats were randomly divided into 2 groups; normal control and a high-fat with cholesterol diet group. The high-fat with cholesterol diet group was fed a 5L79 diet with an added 15% lard and 1% cholesterol supplemented diet for 3 weeks for induction of obesity. After induction, obesity was confirmed by checking obesity indexes, the animals were divided into 4 groups (n=5); first, the normal control (NC), and then taken from the obese model of rats, a high-fat with cholesterol diet obesity control group (HF), 0.5% M. pilosus mycelial extract supplemented high-fat with cholesterol diet group (MPMs), 2% conjugated linoleic acid supplemented high-fat with cholesterol diet group (CLA) for 7 weeks. Body weight gains, obesity indexes, and body fat contents in the experimental groups (MPMs and CLA) were decreased compared with HF group. Feed Efficiency Ratio (FER) in MPMs was significantly lower than that of HF without change of feed intake. These results suggested that the anti-obesity effects of the M. pilosus mycelial extracts (MPMs) could prevent obesity induced by high-fat with cholesterol diet possibly via inhibition of lipid absorption.
#conjugated linoleic acid #high-fat with cholesterol diet #Monascus pilosus mycelial extract #obesity #reactive oxygen species scavenging enzyme activities

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참고문헌 (52)

참고문헌 신청
도명술 / 2007 / 체중조절 기전과 항비만 기능성물질 / 한국식품영양과학회지 36(4):503~513 google schola Arad Y / 1990 / Lovastatin therapy reduces low density lipoprotein apoB levels in subjects with combined hyperlipidemia by reducing the production of apoBcontaining lipoproteins: Implications for the pathophysiology of apoB production / J Lipid Res 31:567~582 google schola Bee G / 2000 / Dietary conjugated linoleic acid consumption during pregnancy and lactation influences growth and tissue composition in weaned pigs / J Nutr 130:2981~2989 google schola Benson BN / 1993 / Dietary energy source and density modulate the expression of immunologic stress in chicks / J Nutr 123:1714~1723 google schola Birch AJ / 1962 / Studies in relation to biosynthesis. Part XXX. Rotiorin, monascin and rubropunctatin / J Chem Soc :3583~3587 google schola

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