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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국응용생명화학회 Journal of applied biological chemistry Journal of applied biological chemistry 제59권 제2호
- 발행연도
- 2016.1
- 수록면
- 137 - 143 (7page)
이용수
초록· 키워드
오류제보하기
Hair is a dermal adjunctive organ that protects the body from external physical and chemical stimuli; hair undergoes anagen, catagen, and telogen phases, with hair-loss occurring during the telogen phase. Alopecia is a condition wherein a person undergoes hair-loss far exceeding the normal amount, owing to diverse external factors. Wild beans are rich in isoflavone and amino acids known to prevent hair-loss; compared to cultivated beans, many wild bean species have higher protein content. This study aimed to develop a hair growth promoting solution, with superior hair growth promoting effects and fewer side effects, using naturally obtained Glycine soja Siebold et Zucc (GSSZ) extracts. Seven-week-old C57BL/6N male mice were classified into different experimental groups. Hair growth was observed in GSSZ-treated mice, and compared against that seen in 3 % minoxidil (MXD, positive control)-treated mice. Visual observations revealed a greater reduction in hair-loss in MXD and GSSZ application groups, compared to that in TXN group (hair loss induction using 1 % testosterone). Evaluation using an image analysis software revealed that compared to the positive control, TXN + GSSZ group showed the highest hair growth. TXN + MXD and control groups exhibited similar follicular cell growth, while the hair growth promotion patterns were similar in the negative control (normal), TXN + GSSZ, and TXN groups, as observed via histological analysis. GSSZ did not induce cytotoxicity (even at 2 mg/mL) in keratinocytes and dermal papilla cells; alternately, dermal papilla cell proliferation was activated in a (GSSZ) concentration-dependent manner. Therefore, the GSSZ extract promoted hair growth and increased hair growth-related cell activity, and could therefore be utilized in alopecia treatment.
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등록된 정보가 없습니다.
참고문헌 (35)
참고문헌 신청
Allegra F / 1970 / Studies of common baldness in the stumptailed macaque. III. DNA synthesis in regrowing hair / Acta Derm-Venereol 50:169~175
Arase S / 1999 / Co-culture of human hair follicles and dermal papilla in a collagen matrix / J Dermatol 17:667~676
Arck PC / 2001 / Indications for a ‘brain-hair follicle axis (BHA)’: inhibition of keratinocyte proliferation and up-regulation of keratinocyte apoptosis in telogen hair follicles by stress and substance P / FASEB J 15:2536~2538
Arck PC / 2003 / Stress inhibits hair growth in mice by induction of premature catagen development and deleterious perifollicular inflammatory events via neuropeptide substance P-dependent pathways / Am J Pathol 162:803~814
Bihl AE / 1990 / Minoxidil sulfate is the active metablite that stimulates hair fillicles / J Invest Dermatol 95:553~557
Arase S / 1999 / Co-culture of human hair follicles and dermal papilla in a collagen matrix / J Dermatol 17:667~676
Arck PC / 2001 / Indications for a ‘brain-hair follicle axis (BHA)’: inhibition of keratinocyte proliferation and up-regulation of keratinocyte apoptosis in telogen hair follicles by stress and substance P / FASEB J 15:2536~2538
Arck PC / 2003 / Stress inhibits hair growth in mice by induction of premature catagen development and deleterious perifollicular inflammatory events via neuropeptide substance P-dependent pathways / Am J Pathol 162:803~814
Bihl AE / 1990 / Minoxidil sulfate is the active metablite that stimulates hair fillicles / J Invest Dermatol 95:553~557
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