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논문 기본 정보

자료유형
학술저널
저자정보
Tosun, Murat (Department of Histology Embryology, Afyon Kocatepe University Medical Faculty) Soysal, Yasemin (Department of Molecular Medicine, Dokuz Eylul University Health Sciences Institute) Mas, Nuket Gocmen (Department of Anatomy, Dokuz Eylul University Medical Faculty) Karabekir, Hamit Selim (Department of Neurosurgery, Dokuz Eylul University Medical Faculty)
저널정보
대한신경외과학회 대한신경외과학회지 대한신경외과학회지 제57권 제3호
발행연도
2015.1
수록면
147 - 151 (5page)

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Objective : Neuroblastoma is one of common childhood tumors. Although its mortality is very high, there is no effective treatment yet. The aim of this project is to evaluate cytotoxic effects of melatonin (MLT) an endogen hormone and 13-cis retinoic acid (13-cis-RA) also named as isotretinoin an analogue of vitamin A on neuroblastoma SH-SY5Y cell line. Methods : In this study, SH-SY5Y cell line was used. After cell culture, the cells were exposed to different doses of MLT and 13-cis-RA. 24 and 48 hours later. While the viabilities was estimated with MTT cell viability assay test, apoptotic indexes were calculated after staining with TUNEL based apoptosis kit. Results : It was observed that MLT has very effective cytotoxic potential than 13-cis-RA on neuroblastoma cell line. At the same time, when MLT and 13-cis-RA were combined, this effect was potentiated. On the other hand, it was found that the effect of 13-cis-RA individually on neuroblastoma cells was very slight. Conclusion : We suggest that in the treatment of patient with neuroblastoma, MLT is very effective and also this effect can be augmented by combination with 13-cis-RA.

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