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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 147 - 151 (5page)
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초록· 키워드
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Objective : Neuroblastoma is one of common childhood tumors. Although its mortality is very high, there is no effective treatment yet. The aim of this project is to evaluate cytotoxic effects of melatonin (MLT) an endogen hormone and 13-cis retinoic acid (13-cis-RA) also named as isotretinoin an analogue of vitamin A on neuroblastoma SH-SY5Y cell line. Methods : In this study, SH-SY5Y cell line was used. After cell culture, the cells were exposed to different doses of MLT and 13-cis-RA. 24 and 48 hours later. While the viabilities was estimated with MTT cell viability assay test, apoptotic indexes were calculated after staining with TUNEL based apoptosis kit. Results : It was observed that MLT has very effective cytotoxic potential than 13-cis-RA on neuroblastoma cell line. At the same time, when MLT and 13-cis-RA were combined, this effect was potentiated. On the other hand, it was found that the effect of 13-cis-RA individually on neuroblastoma cells was very slight. Conclusion : We suggest that in the treatment of patient with neuroblastoma, MLT is very effective and also this effect can be augmented by combination with 13-cis-RA.
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등록된 정보가 없습니다.
참고문헌 (22)
참고문헌 신청
Benitez-King G. / 2003 / Melatonin prevents cytoskeletal alterations and oxidative stress induced by okadaic acid in N1E-115 cells / Exp Neurol 182:151~159
Chetsawang B. / 2006 / Melatonin protects against hydrogen peroxide-induced cell death signaling in SH-SY5Y cultured cells : involvement of nuclear factor kappa B, Bax and Bcl-2 / J Pineal Res 41:116~123
Choi SI. / 2008 / Melatonin prevents nitric oxide-induced apoptosis by increasing the interaction between 14-3-3beta and p-Bad in SK-N-MC cells / J Pineal Res 44:95~100
Dragicevic N. / 2011 / Melatonin treatment restores mitochondrial function in Alzheimer’s mice : a mitochondrial protective role of melatonin membrane receptor signaling / J Pineal Res 51:75~86
García-Santos G. / 2006 / Melatonin induces apoptosis in human neuroblastoma cancer cells / J Pineal Res 41:130~135
Chetsawang B. / 2006 / Melatonin protects against hydrogen peroxide-induced cell death signaling in SH-SY5Y cultured cells : involvement of nuclear factor kappa B, Bax and Bcl-2 / J Pineal Res 41:116~123
Choi SI. / 2008 / Melatonin prevents nitric oxide-induced apoptosis by increasing the interaction between 14-3-3beta and p-Bad in SK-N-MC cells / J Pineal Res 44:95~100
Dragicevic N. / 2011 / Melatonin treatment restores mitochondrial function in Alzheimer’s mice : a mitochondrial protective role of melatonin membrane receptor signaling / J Pineal Res 51:75~86
García-Santos G. / 2006 / Melatonin induces apoptosis in human neuroblastoma cancer cells / J Pineal Res 41:130~135
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