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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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Objective : Optimal treatment decision and estimation of the prognosis in traumatic brain injury (TBI) is currently based on demographic and clinical predictors. But sometimes, there are limitations in these factors. In this study, we analyzed three central nervous system biomarkers in TBI patients, will discuss the roles and clinical applications of biomarkers in TBI. Methods : From July on 2013 to August on 2014, a total of 45 patients were included. The serum was obtained at the time of hospital admission, and biomarkers were extracted with centrifugal process. It was analyzed for the level of S-100 beta (S100B), glial fibrillary acidic protein (GFAP), and ubiquitin carboxy-terminal hydrolase-L1 (UCH-L1). Results : This study included 33 males and 12 females with a mean age of 58.5 (19-84) years. TBI patients were classified into two groups. Group A was severe TBI with Glasgow Coma Scale (GCS) score 3-5 and Group B was mild TBI with GCS score 13-15. The median serum concentration of S100B, GFAP, and UCH-L1 in severe TBI were raised 5.1 fold, 5.5 fold, and 439.1 fold compared to mild injury, respectively. The serum levels of these markers correlated significantly with the injury severity and clinical outcome (p<0.001). Increased level of markers was strongly predicted poor outcomes. Conclusion : S100B, GFAP, and UCH-L1 serum level of were significantly increased in TBI according to severity and associated clinical outcomes. Biomarkers have potential utility as diagnostic, prognostic, and therapeutic adjuncts in the setting of TBI.
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참고문헌 (36)
참고문헌 신청
Alpert JS. / 2000 / Myocardial infarction redefined--a consensus document of The Joint European Society of Cardiology/American College of Cardiology Committee for the redefinition of myocardial infarction / J Am Coll Cardiol 36:959~969
Anderson RE. / 2001 / High serum S100B levels for trauma patients without head injuries / Neurosurgery 48:1255~1258
Baker SP. / 1974 / The injury severity score : a method for describing patients with multiple injuries and evaluating emergency care / J Trauma 14:187~196
Bell MJ. / 1999 / Quinolinic acid in the cerebrospinal fluid of children after traumatic brain injury / Crit Care Med 27:493~497
Berger RP. / 2007 / Serum biomarker concentrations and outcome after pediatric traumatic brain injury / J Neurotrauma 24:1793~1801
Anderson RE. / 2001 / High serum S100B levels for trauma patients without head injuries / Neurosurgery 48:1255~1258
Baker SP. / 1974 / The injury severity score : a method for describing patients with multiple injuries and evaluating emergency care / J Trauma 14:187~196
Bell MJ. / 1999 / Quinolinic acid in the cerebrospinal fluid of children after traumatic brain injury / Crit Care Med 27:493~497
Berger RP. / 2007 / Serum biomarker concentrations and outcome after pediatric traumatic brain injury / J Neurotrauma 24:1793~1801
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