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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2009.1
- 수록면
- 419 - 427 (9page)
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To evaluate the effect of non-animal protein hydrolysates on keratinocyte differentiation, commercially-available soy protein hydrolysates were employed as feed supplements for serumfree culture medium in the absence or presence of bovine pituitary extract (BPE). Supplementation of keratinocyte culture medium containing BPE with Soy Hydrolysate (1 g/L) or Bacto Soytone (1 or 2 g/L) inhibited the mRNA and protein expression levels of early and late differentiation markers, and also helped cells to maintain a small size, an indication of an undifferentiated state. These results show that the supplementation of protein hydrolysates might be helpful to delay keratinocytes differentiation.
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