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자료유형
학술저널
저자정보
Lee, Seung Woong (Division of Biotechnology and Advanced Institute of Environment and Bioscience, Chonbuk National University) Song, Ja-Gyeong (Division of Biotechnology and Advanced Institute of Environment and Bioscience, Chonbuk National University) Hwang, Byung Soon (Division of Biotechnology and Advanced Institute of Environment and Bioscience, Chonbuk National University) Kim, Dae-Won (Division of Biotechnology and Advanced Institute of Environment and Bioscience, Chonbuk National University) Lee, Yoon-Ju (Division of Biotechnology and Advanced Institute of Environment and Bioscience, Chonbuk National University) Woo, E-Eum (Division of Biotechnology and Advanced Institute of Environment and Bioscience, Chonbuk National University) Kim, Ji-Yul (Division of Biotechnology and Advanced Institute of Environment and Bioscience, Chonbuk National University) Lee, In-Kyoung (Division of Biotechnology and Advanced Institute of Environment and Bioscience, Chonbuk National University) Yun, Bong-Sik (Division of Biotechnology and Advanced Institute of Environment and Bioscience, Chonbuk National University)
저널정보
한국균학회 Mycobiology Mycobiology 제42권 제2호
발행연도
2014.1
수록면
185 - 188 (4page)

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We investigated a total of 335 samples of Korean native mushroom extracts as part of our lipoxygenase (LOX) inhibitor screening program. Among the mushroom-methanolic extracts we investigated, 35 exhibited an inhibitory activity greater than 30% against LOX at a concentration of 100 ${\mu}g/mL$. Especially, Collybia maculata, Tylopilus neofelleus, Strobilomyces confusus, Phellinus gilvus, P. linteus, P. baumii, and Inonotus mikadoi exhibited relatively potent LOX inhibitory activities of 73.3%, 51.6%, 52.4%, 66.7%, 59.5%, 100.0%, and 85.2%, respectively. Bioassay-guided fractionation led to the isolation of inoscavin A from the methanolic extract of P. baumii, which showed the most potent activity and was identified by spectroscopic methods. Specifically, inoscavin A exhibited potent LOX inhibitory activity with an $IC_{50}$ value of $6.8{\mu}M$.

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