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논문 기본 정보

자료유형
학술저널
저자정보
Mahmoud, Yehia A.G. (Botany Department [Mycology Laboratory], Faculty of Science, Tanta University) Al-Ghamdi, Abdulaziz Yahya (Biology Department, Faculty of Science, Al Baha University) Abd El-Zaher, Eman H.F. (Botany Department [Mycology Laboratory], Faculty of Science, Tanta University)
저널정보
한국균학회 Mycobiology Mycobiology 제39권 제1호
발행연도
2011.1
수록면
40 - 44 (5page)

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Aspergillus fumigatus is associated with invasive disease aspergillosis in immunocompromised individuals. The major aim of this study was to investigate the biochemical and immunological responses of male Wistar rats against A. fumigatus experimentally-induced pulmonary fungal infection. Nostril experimental exposure of male Wistar rats to a high dose of A. fumigatus freeze-dried preparation for only 24 hr resulted in a significant increase in levels of catalase, nitric oxide and lipid peroxide in lung homogenates, compared to those of the control animals. However, the oxidative status of the lungs of rats challenged with killed fungus did not change significantly, except for the stimulation in the level of lipid peroxide. IgG level was significantly elevated only in rats that received two low doses of fungus, compared to unexposed animals (p < 0.005). Examining the lung of rats exposed to A. fumigatus revealed no abnormal changes, except for pus in bronchial lumen spaces and per bronchial inflammation. Histologically, large numbers of granuloma cells were evident in the lungs of challenged rats, while no granuloma formation was evident in the lungs of rats exposed to killed fungus.

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