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학제간연구 과학기술학 뇌인지과학 기술정책 기타 복합학

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논문 기본 정보

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학술저널
저자정보
Lim, Sungryong (Department of Neurological Surgery, Asan Medical Center, University of Ulsan College of Medicine) Kim, Jeong Hoon (Department of Neurological Surgery, Asan Medical Center, University of Ulsan College of Medicine) Kim, Sun A (Department of Pathology, Asan Medical Center, University of Ulsan College of Medicine) Park, Eun Suk (Department of Neurosurgery, Ulsan University Hospital, University of Ulsan College of Medicine) Ra, Young Shin (Department of Neurological Surgery, Asan Medical Center, University of Ulsan College of Medicine) Kim, Chang Jin (Department of Neurological Surgery, Asan Medical Center, University of Ulsan College of Medicine)
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대한신경외과학회 대한신경외과학회지 대한신경외과학회지 제53권 제5호
발행연도
2013.1
수록면
281 - 287 (7page)

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Objective : Pleomorphic xanthoastrocytoma (PXA) is a rare primary low-grade astrocytic tumor classified as WHO II. It is generally benign, but disease progression and malignant transformation have been reported. Prognostic factors for PXA and optimal therapies are not well known. Methods : The study period was January 2000 to March 2012. Data on MR findings, histology, surgical extents and adjuvant therapies were reviewed in twenty-two patients diagnosed with PXA. Results : The frequent symptoms of PXA included seizures, headaches and neurologic deficits. Tumors were most common in the temporal lobe followed by frontal, parietal and occipital lobes. One patient who died from immediate post-operative complications was excluded from the statistical analysis. Of the remaining 21 patients, 3 (14%) died and 7 (33%) showed disease progression. Atypical tumor location (p<0.001), peritumoral edema (p=0.022) and large tumor size (p=0.048) were correlated with disease progression, however, Ki-67 index and necrosis were not statistically significant. Disease progression occurred in three (21%) of 14 patients who underwent GTR, compared with 4 (57%) of 7 patients who did not undergo GTR, however, it was not statistically significant. Ten patients received adjuvant radiotherapy and the tumors were controlled in 5 of these patients. Conclusion : The prognosis for PXA is good; in our patients overall survival was 84%, and event-free survival was 59% at 3 years. Atypical tumor location, peritumoral edema and large tumor size are significantly correlated with disease progression. GTR may provide prolonged disease control, and adjuvant radiotherapy may be beneficial, but further study is needed.
#Pleomorphic xanthoastrocytoma #Prognosis #outcome #Radiotherapy

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참고문헌 (36)

참고문헌 신청
Berger MS / 1994 / The effect of extent of resection on recurrence in patients with low grade cerebral hemisphere gliomas / Cancer 74:1784~1791 google schola Crespo-Rodríguez AM / 2007 / MR and CT imaging of 24 pleomorphic xanthoastrocytomas (PXA) and a review of the literature / Neuroradiology 49:307~315 google schola Davies KG / 1994 / Pleomorphic xanthoastrocytoma--report of four cases, with MRI scan appearances and literature review / Br J Neurosurg 8:681~689 google schola Fouladi M / 2001 / Pleomorphic xanthoastrocytoma : favorable outcome after complete surgical resection / Neuro Oncol 3:184~192 google schola Fu YJ / 2010 / Intraventricular pleomorphic xanthoastrocytoma with anaplastic features / Neuropathology 30:443~448 google schola

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