Prognostic Factors and Clinical Outcomes of Acute Intracerebral Hemorrhage in Patients with Chronic Kidney Disease

Kim, Jin Kyu; Shin, Jun Jae; Park, Sang Keun; Hwang, Yong Soon; Kim, Tae Hong; Shin, Hyung Shik

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자료유형: 학술저널

저자정보: Kim, Jin Kyu (Department of Neurosurgery, Sanggye Paik Hospital, Inje University College of Medicine) Shin, Jun Jae (Department of Neurosurgery, Sanggye Paik Hospital, Inje University College of Medicine) Park, Sang Keun (Department of Neurosurgery, Sanggye Paik Hospital, Inje University College of Medicine) Hwang, Yong Soon (Department of Neurosurgery, Sanggye Paik Hospital, Inje University College of Medicine) Kim, Tae Hong (Department of Neurosurgery, Sanggye Paik Hospital, Inje University College of Medicine) Shin, Hyung Shik (Department of Neurosurgery, Sanggye Paik Hospital, Inje University College of Medicine)

저널정보: 대한신경외과학회 대한신경외과학회지 대한신경외과학회지 제54권 제4호

발행연도: 2013.1

수록면: 296 - 301 (6page)

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Objective : We conducted a retrospective study examining the outcomes of intracerebral hemorrhage (ICH) in patients with chronic kidney disease (CKD) to identify parameters associated with prognosis. Methods : From January 2001 to June 2008, we treated 32 ICH patients (21 men, 11 women; mean age, 62 years) with CKD. We surveyed patients age, sex, underlying disease, neurological status using Glasgow Coma Scale (GCS), ICH volume, hematoma location, accompanying intraventricular hemorrhage, anti-platelet agents, initial and 3rd day systolic blood pressure (SBP), clinical outcome using the modified Rankin Scale (mRS) and complications. The severity of renal functions was categorized using a modified glomerular filtration rate (mGFR). Multifactorial effects were identified by regression analysis. Results : The mean GCS score on admission was $9.4{\pm}4.4$ and the mean mRS was $4.3{\pm}1.8$. The overall clinical outcomes showed a significant relationship on initial neurological status, hematoma volume, and mGFR. Also, the outcomes of patients with a severe renal dysfunction were significantly different from those with mild/moderate renal dysfunction (p<0.05). Particularly, initial hematoma volume and sBP on the 3rd day after ICH onset were related with mortality (p<0.05). However, the other factors showed no correlation with clinical outcome. Conclusion : Neurological outcome was based on initial neurological status, renal function and the volume of the hematoma. In addition, hematoma volume and uncontrolled blood pressure were significantly related to mortality. Hence, the severity of renal function, initial neurological status, hematoma volume, and uncontrolled blood pressure emerged as significant prognostic factors in ICH patients with CKD.

#Intracerebral hemorrhage #Chronic kidney disease #Renal failure #Modified Rankin Scale #Prognosis #Mortality

참고문헌 (23)

참고문헌 신청

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