지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한핵의학회 Nuclear medicine and molecular imaging : NMMI Nuclear medicine and molecular imaging : NMMI 제45권 제3호
- 발행연도
- 2011.1
- 수록면
- 161 - 168 (8page)
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초록· 키워드
오류제보하기
Purpose Salivary gland scintigraphy (SGS) provides an objective means of diagnosing salivary gland dysfunction in Sj$\ddot{o}$gren's syndrome (SS) patients and in thyroid cancer patients after radioactive iodine (RAI) therapy. In the present study, SGS was performed in SS patients and in thyroid cancer patients post-RAI, and scintigraphic parameters were compared. Methods Twenty-eight SS patients (males:females=1:27, age $53.3{\pm}11.9$ years), 28 controls (males:females=3:25, age $54.1{\pm}10.1$ years), and 92 thyroid cancer patients (males:females=28:64, age $46.2{\pm}12.9$) who had undergone a session of high-dose RAI therapy (mean dose, $5.2{\pm}1.5$ GBq) were included. SGS was performed using Tc-99m pertechnetate (925 MBq). Scintigraphic parameters (parotid uptake ratio PU, submandibular uptake ratio SU, percentage parotid excretion %PE, and percentage submandibular excretion %SE) were measured and compared for SS, thyroid cancer post-RAI, and control patients. Results PU, SU, %SE, and %PE were all significantly lower in SS than in post-RAI thyroid cancer or control patients (p<0.05), whereas only %PE was significantly lower in post-RAI thyroid cancer patients than in controls (p<0.05). SU and %SE were found to be correlated with the unstimulated whole salivary flow rate. Conclusion Scintigraphic parameters derived from SGS can play a crucial role in the detection of salivary gland dysfunction in SS patients and in post-RAI thyroid cancer patients.
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