Expression of pro-opiomelanocortin and agouti-related protein in the hypothalamus of caffeine-administered rats

Jeong, Joo-Yeon; Ku, Bo-Mi; Lee, Yeon-Kyung; Ryu, Jin-Hyun; Choi, Jung-Il; Kim, Joon-Soo; Cho, Yong-Woon; Roh, Gu-Seob; Kim, Hyun-Joon; Cho, Gyeong-Jae; Choi, Wan-Sung; Kang, Sang-Soo

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자료유형: 학술저널

저자정보: Jeong, Joo-Yeon (Department of Anatomy & Neurobiology, Institute of Health Sciences, Medical Research Center for Neural Dysfunction, School of Medicine, Gyeongsang National University) Ku, Bo-Mi (Department of Anatomy & Neurobiology, Institute of Health Sciences, Medical Research Center for Neural Dysfunction, School of Medicine, Gyeongsang National University) Lee, Yeon-Kyung (Department of Anatomy & Neurobiology, Institute of Health Sciences, Medical Research Center for Neural Dysfunction, School of Medicine, Gyeongsang National University) Ryu, Jin-Hyun (Department of Anatomy & Neurobiology, Institute of Health Sciences, Medical Research Center for Neural Dysfunction, School of Medicine, Gyeongsang National University) Choi, Jung-Il (Department of Anatomy & Neurobiology, Institute of Health Sciences, Medical Research Center for Neural Dysfunction, School of Medicine, Gyeongsang National University) Kim, Joon-Soo (Department of Neurosurgery, Samsung Changwon Hospital, Sungkyunkwan University, School of Medicine) Cho, Yong-Woon (Department of Neurosurgery, Samsung Changwon Hospital,) Roh, Gu-Seob Kim, Hyun-Joon Cho, Gyeong-Jae Choi, Wan-Sung Kang, Sang-Soo

저널정보: 한국통합생물학회 Animal cells and systems Animal cells and systems 제15권 제3호

발행연도: 2011.1

수록면: 203 - 210 (8page)

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In the present study, we examined the effects of caffeine on food intake and body weight, and pro-opiomelanocortin (POMC) and agouti-related protein (AgRP) expression in the hypothalamus. Rats were administered intraperitoneally with 100 mg/kg caffeine (a high, non-toxic dose) or saline during the light phase. Intraperitoneal administration of caffeine induced a significant reduction in food intake and body weight 12 hr after treatment. In addition, POMC expression was significantly increased and AgRP expression was decreased in the arcuate nucleus (Arc) after caffeine treatment. These results demonstrate that administration of caffeine up-regulates POMC expression and down-regulates AgRP expression in the Arc, suggesting that the activation of the hypothalamic POMC neurons and inhibition of the AgRP neurons might play a role in the regulation of food intake and body weight by caffeine.

#body weight #food intake #POMC #AgRP #caffeine

참고문헌 (37)

참고문헌 신청

Adan RA / 1997 / Molecular pharmacology of neural melanocortin receptors / Receptors Channels 5(3):215~223

Astrup A / 1992 / The effect and safety of an ephedrine/caffeine compound compared to ephedrine, caffeine and placebo in obese subjects on an energy restricted diet. A double blind trial / Int J Obes Relat Metab Disord 16(4):269~277

Belgardt BF / 2009 / Hormone and glucose signaling in POMC and AgRP neurons / J Physiol 587(22):5305~5314

Bouret SG / 2004 / Formation of projection pathways from the arcuate nucleus of the hypothalamus to hypothalamic regions implicated in the neural control of feeding behavior in mice / J Neurosci 24(11):2797~2805

Broberger C / 2001 / Hypothalamic and vagal neuropeptide circuitries regulating food intake / Physiol Behav 74(4):669~682