지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한생식의학회 Clinical and experimental reproductive medicine : CERM Clinical and experimental reproductive medicine : CERM 제38권 제1호
- 발행연도
- 2011.1
- 수록면
- 42 - 46 (5page)
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초록· 키워드
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Objective: This study was aimed to investigate endometrial histology and to find predictable clinical factors for endometrial disease (hyperplasia or cancer) in women with polycystic ovary syndrome (PCOS). Methods: We investigated the endometrial histology and analyzed the relationship between endometrial histology and clinical parameters, such as LH, FSH, estradiol, testosterone, fasting and 2 hours postprandial glucose and insulin, insulin resistance, body mass index, endometrial thickness, menstrual status from 117 women with PCOS. Statistical analysis was performed with chi square and t-test, p-value<0.05 was considered as statistically significant. And receiver operating characteristic curve was used to find predictable clinical factors for endometrial disease and to decide the cuff off values. Results: In 117 women with PCOS, endometrial histologic profiles are as follows: proliferative phase in 90 women (76.9%), endometrial hyperplasia in 25 women (21.4%), and endometrial cancer in 2 women (1.7%). Of 25 women with endometrial hyperplasia, simple hyperplasia without atypia, complex hyperplasia without atypia and complex hyperplasia with atypia were diagnosed in 15 (12.8%), 6 (5.1%), 4 (3.4%) women, respectively. Age and endometrial thickness were significantly related with endometrial disease, p=0.013 and p=0.001, respectively. At the cut off level of 25.5 years in age, sensitivity and specificity predicting for endometrial disease were 70.4% and 55.6%, respectively (p=0.023). At the cut off level of 8.5 mm in endometrial thickness, sensitivity and specificity were 77.8% and 56.7%, respectively (p=0.000). Conclusion: In women with PCOS, the incidence of endometrial hyperplasia and cancer were 21.4% and 1.7%. The age and endometrial thickness may be used as clinical determining factors for endometrial biopsy.
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참고문헌 (16)
참고문헌 신청
Ehrmann DA / 2005 / Polycystic ovary syndrome / N Engl J Med 352:1223~1236
Rotterdam ESHRE/ASRM-Sponsored PCOS Consensus Workshop Group / 2004 / Revised 2003 consensus on diagnostic criteria and longterm health risks related to polycystic ovary syndrome / Fertil Steril 81:19~25
Giudice LC / 2006 / Endometrium in PCOS: implantation and predisposition to endocrine CA / Best Pract Res Clin Endocrinol Metab 20:235~244
Iatrakis G / 2006 / Polycystic ovarian syndrome, insulin resistance and thickness of the endometrium / Eur J Obstet Gynecol Reprod Biol 127:218~221
Balen A / 2001 / Polycystic ovary syndrome and cancer / Hum Reprod Update 7:522~525
Rotterdam ESHRE/ASRM-Sponsored PCOS Consensus Workshop Group / 2004 / Revised 2003 consensus on diagnostic criteria and longterm health risks related to polycystic ovary syndrome / Fertil Steril 81:19~25
Giudice LC / 2006 / Endometrium in PCOS: implantation and predisposition to endocrine CA / Best Pract Res Clin Endocrinol Metab 20:235~244
Iatrakis G / 2006 / Polycystic ovarian syndrome, insulin resistance and thickness of the endometrium / Eur J Obstet Gynecol Reprod Biol 127:218~221
Balen A / 2001 / Polycystic ovary syndrome and cancer / Hum Reprod Update 7:522~525
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