지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한생식의학회 Clinical and experimental reproductive medicine : CERM Clinical and experimental reproductive medicine : CERM 제39권 제1호
- 발행연도
- 2012.1
- 수록면
- 10 - 14 (5page)
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초록· 키워드
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The ovarian follicles develop initially from primordial follicles. The majority of ovarian primordial follicles are maintained quiescently as a reserve for the reproductive life span. Only a few of them are activated and develop to an advanced follicular stage. The maintenance of dormancy and activation of primordial follicles are controlled by coordinated actions of a suppressor/activator with close communications with somatic cells and intra-oocyte signaling pathways. Many growth factors and signaling pathways have been identified and the transforming growth factor-beta superfamily plays important roles in early folliculogenesis. However, the mechanism of maintaining the dormancy and survival of primordial follicles has remained unknown for decades. Recently, since the first finding that all primordial follicles are activated prematurely in mice deficient forkhead box O3a, phosphatidylinositol 3 kinase/phosphatase and tensin homolog (PTEN) signaling pathway was reported to be important in the regulation of dormancy and initial follicular activation. With these informations on early folliculogenesis, clinical application can be expected such as in vitro maturation of immature oocytes or in vitro activation of follicles by PTEN inhibitor in cryopreserved ovarian cortical tissues for fertility preservation.
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참고문헌 (39)
참고문헌 신청
McGee EA / 2000 / Initial and cyclic recruitment of ovarian follicles / Endocr Rev 21:200~214
Elvin JA / 1998 / Mouse models of ovarian failure / Rev Reprod 3:183~195
Eppig JJ / 2002 / The mammalian oocyte orchestrates the rate of ovarian follicular development / Proc Natl Acad Sci U S A 99:2890~2894
Castrillon DH / 2003 / Suppression of ovarian follicle activation in mice by the transcription factor Foxo3a / Science 301:215~218
John GB / 2008 / Foxo3 is a PI3Kdependent molecular switch controlling the initiation of oocyte growth / Dev Biol 321:197~204
Elvin JA / 1998 / Mouse models of ovarian failure / Rev Reprod 3:183~195
Eppig JJ / 2002 / The mammalian oocyte orchestrates the rate of ovarian follicular development / Proc Natl Acad Sci U S A 99:2890~2894
Castrillon DH / 2003 / Suppression of ovarian follicle activation in mice by the transcription factor Foxo3a / Science 301:215~218
John GB / 2008 / Foxo3 is a PI3Kdependent molecular switch controlling the initiation of oocyte growth / Dev Biol 321:197~204
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