Fabrication and Evaluation of Polyelectrolyte Complexes of Dextran Derivatives for Drug Coating of Coronary Stents

Jang, Eun-Jae; Lee, So-Youn; Bae, In-Ho; Park, Dae Sung; Jeong, Myung Ho; Park, Jun-Kyu

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자료유형: 학술저널

저자정보: Jang, Eun-Jae (Biopharmaceutical Research Center) Lee, So-Youn (The Cardiovascular Convergence Research Center of Chonnam National University, Hospital Designated by Ministry of Health and Welfare) Bae, In-Ho (The Cardiovascular Convergence Research Center of Chonnam National University, Hospital Designated by Ministry of Health and Welfare) Park, Dae Sung (The Cardiovascular Convergence Research Center of Chonnam National University, Hospital Designated by Ministry of Health and Welfare) Jeong, Myung Ho (Department of Cardiology, Chonnam National University Hospital) Park, Jun-Kyu (CGBio Co. Ltd)

저널정보: 한국공업화학회 공업화학 공업화학 제30권 제5호

발행연도: 2019.1

수록면: 586 - 590 (5page)

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The aim of this study was to fabricate a dextran polyelectrolyte multi-layer on a bare metal stent (BMS) and to evaluate bio-physical properties of the layer. Diethylaminoethyl-dextran (DEAE-D) as a polycation and dextran sulfate (DS) as a polyanion were successively coated on the bare metal stent by a well-known layer-by-layer procedure. The morphology of the stent surface and its cell adhesion were studied after each coating step by scanning electron microscopy. The stent showed more blotched and slightly rougher morphology after dextran-DS coating. The contact angle of the DEAE-DS group ($39.5{\pm}0.15^{\circ}$) was significantly higher than that of the BMS group ($45.16{\pm}0.08^{\circ}$), indicating the improvement of hydrophilic. The SMC proliferation inhibition in the DEAE-DS-coated stent group ($20.9{\pm}0.04%$) was stronger than that in the control group ($21.7{\pm}0.10%$ in DS-coated group only). The DEAE-DS coating is desired for stent coating materials with biocompatibility and anti-restenosis effect.

#Dual drug-eluting stent #Electrolyte coating #Dextran #Nature polymer #Anti-restenosis

참고문헌 (28)

참고문헌 신청

S. Tsimikas / 2006 / Drug-eluting stents and late adverse clinical outcomes lessons learned, lessons awaited / J. Am. Coll. Cardiol 47:2112~2115

G. W. Jeong / The developing trend in bioresorbable stent for trement of coronary artery disease / Appl. Chem. Eng 29(5):497~502

F. G. Welt / 2002 / Inflammation and restenosis in the stent era / Arterioscler. Thromb. Vasc. Biol 22:1769~1776

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S. Meng / 2009 / The effect of a layer-by-layer chitosan-heparin coating on the endothelialization and coagulation properties of a coronary stent system / Biomaterials 30:2276~2283

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