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논문 기본 정보

자료유형
학술저널
저자정보
Kim, Jun-Sub (Department of Biotechnology, Korea National University of Transportation) Yu, Il-Hwan (Department of Biotechnology, Korea National University of Transportation) Joo, Ji-Hye (Department of Biotechnology, Korea National University of Transportation) Nam, Gyeong Hoe (Department of Biotechnology, Korea National University of Transportation) Jung, Kyung-Hwan (Department of Biotechnology, Korea National University of Transportation) Chung, Young Soo (Beauty Cosmetic Co., Ltd.) Lee, Hyang-Yeol (Department of Biotechnology, Korea National University of Transportation)
저널정보
한국유화학회 한국유화학회지 한국응용과학기술학회지 제33권 제4호
발행연도
2016.1
수록면
788 - 794 (7page)

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Vinca alkaloids from plant Vinca minor have been investigated for their effects of tyrosinase inhibition, stimulation of ROS generation and increasement of cell migration activity. The methanolic crude extract and the water-soluble fraction exhibited $IC_{50}$ value of 3.1 mg/mL and 2.1 mg/mL. Vinca minor extract treatment significantly increased ROS levels in HaCaT cells, in a concentration-dependent manner. Treatments of Vinca minor extract led to increase wound closure when compared with non-treatment. Low dose (0.1% or 0.3%) of extracts have not significantly affected, compared with that in controls. By contrast, 0.5% extract have dramatic effect on wound healing activity of keratinocytes. Effects of Vinca minor extract in a filter-based cell mobility assay appear similar to that of wound closure assay, which suggests that the Vinca minor extract have wound healing effects on skin.

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