Prognostic Value of HPV18 DNA Viral Load in Patients with Early-Stage Neuroendocrine Carcinoma of the Uterine Cervix

Siriaunkgul, Sumalee; Utaipat, Utaiwan; Suwiwat, Supaporn; Settakorn, Jongkolnee; Sukpan, Kornkanok; Srisomboon, Jatupol; Khunamornpong, Surapan

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저자정보: Siriaunkgul, Sumalee (Department of Pathology, Faculty of Medicine, Chiang Mai University) Utaipat, Utaiwan (Research Institute for Health Sciences, Chiang Mai University) Suwiwat, Supaporn (Department of Pathology, Faculty of Medicine, Prince of Songkla University) Settakorn, Jongkolnee (Department of Pathology, Faculty of Medicine, Chiang Mai University) Sukpan, Kornkanok (Department of Pathology, Faculty of Medicine, Chiang Mai University) Srisomboon, Jatupol (Department of Obstetrics and Gynecology, Faculty of Medicine, Chiang Mai University) Khunamornpong, Surapan (Department of Pathology, Faculty of Medicine, Chiang Mai University)

저널정보: 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제13권 제7호

발행연도: 2012.1

수록면: 3,281 - 3,285 (5page)

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Objectives: To evaluate the clinicopathologic correlation and prognostic value of HPV18 DNA viral load in patients with early-stage cervical neuroendocrine carcinoma (NECA). Methods: Formalin-fixed, paraffin-embedded tissue of cervical NECA patients with known HPV18 infection and clinicopathologic data including follow-up results were collected. The HPV18 DNA load was assessed with quantitative PCR targeting the HPV18 E6E7 region. Results: Twenty-one patients with early-stage (IB-IIA) cervical NECA were identified. HPV18 DNA viral load ranged from 0.83 to 55,174 copies/cell (median 5.90). Disease progression, observed in 10 cases (48%), was not significantly associated with any clinicopathologic variables. However, the group of patients with progressive disease tended to have a higher rate of pelvic lymph node metastasis (50% versus 9%, p=0.063) and a lower median value of HPV18 DNA viral load (4.37 versus 8.17 copies/cell, p=0.198) compared to the non-recurrent group. When stratified by a cut-off viral load value of 5.00 copies/cell, the group of patients with viral load ${\leq}5.00$ copies/cell had a significantly shorter disease-free survival than the group with viral load >5.00 copies/cell (p=0.028). The group with a lower viral load also tended to have a higher rate of disease progression (75% versus 31%, p=0.080). No significant difference in the other clinicopathologic variables between the lower and higher viral load groups was identified. Conclusion: HPV18 DNA viral load may have a prognostic value in patients with early-stage NECA of the cervix. A low viral load may be predictive of shortened disease-free survival in these patients.

#Human papillomavirus #HPV) #HPV18 #DNA viral load #prognosis #neuroendocrine carcinoma

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Siriaunkgul, Sumalee

소속기관 Division of Gynecologic Pathology, Department of Pathology Faculty of Medicine, Chiang Mai Universit