Improving Participation in Colorectal Cancer Screening: a Randomised Controlled Trial of Sequential Offers of Faecal then Blood Based Non-Invasive Tests

Symonds, Erin L; Pedersen, Susanne; Cole, Stephen R; Massolino, Joseph; Byrne, Daniel; Guy, John; Backhouse, Patricia; Fraser, Robert J; LaPointe, Lawrence; Young, Graeme P

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자료유형: 학술저널

저자정보: Symonds, Erin L (Flinders Centre for Innovation in Cancer) Pedersen, Susanne (Clinical Genomics Pty Ltd.) Cole, Stephen R (Flinders Centre for Innovation in Cancer) Massolino, Joseph (East Adelaide Healthcare) Byrne, Daniel (Chandlers Hill Surgery) Guy, John (Flagstaff Hill Medical Centre) Backhouse, Patricia (East Adelaide Healthcare) Fraser, Robert J (Flinders Centre for Innovation in Cancer) LaPointe, Lawrence (Clinical Genomics Pty Ltd.) Young, Graeme P (Flinders Centre for Innovation in Cancer)

저널정보: 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제16권 제18호

발행연도: 2015.1

수록면: 8,455 - 8,460 (6page)

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Background: Poor participation rates are often observed in colorectal cancer (CRC) screening programs utilising faecal occult blood tests. This may be from dislike of faecal sampling, or having benign bleeding conditions that can interfere with test results. These barriers may be circumvented by offering a blood-based DNA test for screening. The aim was to determine if program participation could be increased by offering a blood test following faecal immunochemical test (FIT) non-participation. Materials and Methods: People were invited into a CRC screening study through their General Practice and randomised into control or intervention (n=600/group). Both groups were mailed a FIT (matching conventional screening programs). Participation was defined as FIT completion within 12wk. Intervention group non-participants were offered a screening blood test (methylated BCAT1/IKZF1). Overall participation was compared between the groups. Results: After 12wk, FIT participation was 82% and 81% in the control and intervention groups. In the intervention 96 FIT nonparticipants were offered the blood test - 22 completed this test and 19 completed the FIT instead. Total screening in the intervention group was greater than the control (88% vs 82%, p<0.01). Of 12 invitees who indicated that FIT was inappropriate for them (mainly due to bleeding conditions), 10 completed the blood test (83%). Conclusions: Offering a blood test to FIT non-participants increased overall screening participation compared to a conventional FIT program. Blood test participation was particularly high in invitees who considered FIT to be inappropriate for them. A blood test may be a useful adjunct test within a FIT program.

#Colorectal cancer #screening #faecal immunochemical test #methylated blood test #participation #FOBT

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