ADPRT Val762Ala and XRCC1 Arg194Trp Polymorphisms and Risk of Gastric Cancer in Sichuan of China

Wen, Yuan-Yuan; Pan, Xiong-Fei; Loh, Marie; Tian, Zhi; Yang, Shu-Juan; Lv, Si-Han; Huang, Wen-Zhi; Huang, He; Xie, Yao; Soong, Richie; Yang, Chun-Xia

추천

검색

자료유형: 학술저널

저자정보: Wen, Yuan-Yuan (Department of Epidemiology, West China School of Public Health, Sichuan University) Pan, Xiong-Fei (Department of Epidemiology, West China School of Public Health, Sichuan University) Loh, Marie (Cancer Science Institute of Singapore, National University of Singapore) Tian, Zhi (Department of Epidemiology, West China School of Public Health, Sichuan University) Yang, Shu-Juan (Department of Child and Adolescent Health, West China School of Public Health, Sichuan University) Lv, Si-Han (Department of Epidemiology, West China School of Public Health, Sichuan University) Huang, Wen-Zhi (Department of Epidemiology, West China School of Public Health, Sichuan University) Huang, He (Department of Epidemiology, West China School of Public Health, Sichuan University) Xie, Yao (Department of Epidemiology, West China School of Public Health, Sichuan University) Soong, Richie (Cancer Science Institute of Singapore, National University of Singapore) Yang, Chun-Xia (Department of Epidemiology, West China School of Public Health, Sichuan University)

저널정보: 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제13권 제5호

발행연도: 2012.1

수록면: 2,139 - 2,144 (6page)

이용수

📌

연구주제

📖

연구배경

🔬

연구방법

🏆

연구결과

초록· 키워드

오류제보하기

Objective: Gastric cancer remains a major health problem in China. We hypothesized that XRCC1 Arg194Trp and ADPRT Val762Ala may be associated with risk. Methods: We designed a multicenter 1:1 matched case-control study of 307 pairs of gastric cancers and controls between October 2010 and August 2011. XRCC1 Arg194Trp and ADPRT Val762Ala were sequenced, and demographic data as well as lifestyle factors were collected using a self-designed questionnaire. Results: Individuals carrying XRCC1 Trp/Trp or Arg/Trp variant genotype had a significantly increased risk of gastric cancer (OR, 1.718; 95% CI, 1.190-2.479), while the OR for ADPRT Val762Ala variant genotype (Ala/Ala or Val/Ala) was 1.175 (95% CI, 0.796-1.737). No gene-gene or gene-environment interactions were found. In addition, family history of cancer and drinkers proportion were higher among cases than among controls (P<0.05). Conclusions: XRCC1 194 Arg/Trp or Trp/Trp genotype, family history of cancer, and drinking are suspected risk factors of gastric cancer from our study. Our findings may offer insight into further similar large gene-environment and gene-gene studies in this region.

#Gastric cancer #XRCC1 #ADPRT #polymorphisms #risk #China

참고문헌 (0)

참고문헌 신청

참고문헌이 DBpia에서 서비스 중이라면, [참고문헌 신청]을 통해 등록해보세요