Up-regulation of Thy-1 Promotes Invasion and Metastasis of Hepatocarcinomas

Cheng, Bian-Qiao; Jiang, Yi; Li, Dong-Liang; Fan, Jing-Jing; Ma, Ming

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자료유형: 학술저널

저자정보: Cheng, Bian-Qiao (Department of Hepatology Center, Fuzhou General Hospital, Nanjing Military Area Command) Jiang, Yi (Department of Hepatology Center, Fuzhou General Hospital, Nanjing Military Area Command) Li, Dong-Liang (Department of Hepatology Center, Fuzhou General Hospital, Nanjing Military Area Command) Fan, Jing-Jing (Department of Hepatology Center, Fuzhou General Hospital, Nanjing Military Area Command) Ma, Ming (Department of Hepatology Center, Fuzhou General Hospital, Nanjing Military Area Command)

저널정보: 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제13권 제4호

발행연도: 2012.1

수록면: 1,349 - 1,353 (5page)

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Increasing evidence has revealed that thy-1 was a potential stem cell marker of liver cancer, but no data have been shown on how thy-1 regulates the pathophysiology of liver cancer, such as proliferation, apoptosis, invasion and migration. We previously demonstrated that thy-1 was expressed in about 1% of hepg2 cells, thy-1+hepg2 cells, but not thy-1-, demonstrating high tumorigenesis on inoculation $0.5{\times}10^5$ cells per BACA/LA mouse after 2 months. In the present study, our results showed that higher expression of thy-1 occurs in 72% (36/50 cases) of neoplastic hepatic tissues as compared to 40% (20/50 cases) of control tissues, and the expression of thy-1 is higher in poorly differentiated liver tumors than in the well-differentiated ones. In addition, thy-1 expression was detected in 85% of blood samples from liver cancer patients, but none in normal subjects or patients with cirrhosis or hepatitis. There was a significant negative correlation between thy-1expression and E-cadherin expression (a marker of invasion and migraton), but not between thy-1 expression and AFP expression in all the liver cancer and blood samples. We further investigated the relationship between thy-1 and E-cadherin in liver cancer hepg2 cell line which was transfected with pReceiver-M29/thy-1 eukaryotic expression vector followed by aspirin treatment. Lower expression of E-cadherin but higher expressions of thy-1 were detected in hepg2 cells transfected with pReceiver-M29/thy-1. Taken together, our study suggested that thy-1 probably regulates liver cancer invasion and migration.

#Invasion #migration #thy-1 #hepatocarcinomas

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