Clinicopathological Significance of Osteopontin in Cholangiocarcinoma Cases

Laohaviroj, Marut; Chamgramol, Yaovalux; Pairojkul, Chawalit; Mulvenna, Jason; Sripa, Banchob

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자료유형: 학술저널

저자정보: Laohaviroj, Marut (Department of Pathology, Faculty of Medicine, Khon Kaen University) Chamgramol, Yaovalux (Department of Pathology, Faculty of Medicine, Khon Kaen University) Pairojkul, Chawalit (Department of Pathology, Faculty of Medicine, Khon Kaen University) Mulvenna, Jason (Infectious Disease and Cancer, QIMR Berghofer Medical Research Institute) Sripa, Banchob (Department of Pathology, Faculty of Medicine, Khon Kaen University)

저널정보: 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제17권 제1호

발행연도: 2016.1

수록면: 201 - 205 (5page)

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Cholangiocarcinoma (CCA) is generally a rare primary liver tumor of the bile duct with extremely poor clinical outcomes due to late diagnosis. Osteopontin (OPN) is the most abundant expressed gene in intrahepatic CCA and its involvement in tumor aggressiveness suggests it could be a useful prognostic biomarker. However, the prognostic significance of OPN expression in CCA is still controversial. We therefore immunohistochemically studied OPN expression in 354 resected CCAs and correlated the results with patient clinicopathological parameters. OPN expression was separately scored according to the percentage of cancer cells or degree of stromal tissue staining and classified as low (score 0-1) and high (score 2-3). OPN expression in CCA cells was found in 177 out of 354 patients (56.5%), whereas stroma was positive in 185 out of 354 patients (52.3%). Univariate analysis with several of the aforementioned parameters revealed that stromal but not cancer cell OPN expression was significantly associated with tumor size, tumor direct invasion into normal liver parenchyma, regional lymph node metastasis and higher staging. The combination of cancer cell and stromal OPN expression demonstrated a positive trend for linkage with lymph node metastasis. Multivariate analysis identified gender, the presence of lymphatic permeation and lymph node metastasis, but not OPN expression, as independent prognostic factors. This study confirms the presence of stromal OPN expression in tumor aggressiveness but not survival in CCA patients.

#Cholangiocarcinoma #osteopontin #biomarker #prognostic marker #immunohistochemistry

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