Breast Cancer Subtypes Identified by the ER, PR and HER-2 Status in Thai Women

Chuthapisith, Suebwong; Permsapaya, Watthanasak; Warnnissorn, Malee; Akewanlop, Charuwan; Sirivatanauksorn, Vorapan; Osoth, Poramaporn Prasarttong

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저자정보: Chuthapisith, Suebwong (Department of Surgery, Faculty of Medicine Siriraj Hospital, Mahidol University) Permsapaya, Watthanasak (Department of Surgery, Faculty of Medicine Siriraj Hospital, Mahidol University) Warnnissorn, Malee (Department of Pathology, Faculty of Medicine Siriraj Hospital, Mahidol University) Akewanlop, Charuwan (Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University) Sirivatanauksorn, Vorapan (Department of Biochemistry, Faculty of Medicine Siriraj Hospital, Mahidol University) Osoth, Poramaporn Prasarttong (Department of Surgery, Faculty of Medicine Siriraj Hospital, Mahidol University)

저널정보: 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제13권 제2호

발행연도: 2012.1

수록면: 459 - 462 (4page)

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Expression of estrogen-receptor (ER), progesterone-receptor (PR) and HER-2 has recently been linked with various breast cancer subtypes identified by gene microarray. This study aimed to document breast cancer subtypes based on ER, PR and HER-2 status in Thai women, where expression of these subtypes may not be similar to those evident in Western women. During 2009 to 2010, histological findings from 324 invasive ductal carcinomas (IDC) at Siriraj Hospital were studied. Various subtypes of IDC were identified according to expression of ER, PR and HER-2: luminal-A (ER+;PR+/-;HER-2-), luminal-B (ER+;PR+/-;HER-2 +), HER-2 (ER-;PR- ;HER-2+) and basal-like (ER-;PR-;HER-2-). As well, associations of tumor size, tumor grade, nodal status, angiolymphatic invasion (ALI), multicentricity and multifocality with different breast cancer subtypes were studied. Of 324 IDCs, 143 (44.1%), 147 (45.4%), 15 (4.6%) and 12 (3.7%) were T1, T2, T3 and T4, respectively. Most tumors were grade 2 (54.9%) and had no nodal involvement (53.4%). According to ER, PR and HER-2 status, 192 (59.3%), 40 (12.3%), 43 (13.3%) and 49 (15.1%) tumors were luminal-A, luminal-B, HER-2 and basal-like subtypes. HER-2 subtype presented with large tumor (p=0.04, ANOVA). Luminal-A IDC was associated with single foci (p<0.01, ${\chi}^2$). HER-2 and basal-like subtypes were likely to have high tumor grade (p<0.01, ${\chi}^2$). In addition, HER-2 subtype had higher number of nodal involvement (p=0.048, ${\chi}^2$). In conclusion, the luminal-A subtype accounted for the majority of IDCs in Thai women. Percentages of HER-2 and basal-like IDCs were high, compared with a recent study from the USA. The HER-2 subtype was related with high nodal invasion. The findings may highlight biological differences between IDCs occurring in Asian and Western women.

#Breast cancer subtype #ER #PR #HER 2 #Thai cases

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