Gallbladder Cancer: a Subtype of Biliary Tract Cancer Which is a Current Challenge in China

Qu, Kai; Liu, Si-Nan; Chang, Hu-Lin; Liu, Chang; Xu, Xin-Sen; Wang, Rui-Tao; Zhou, Lei; Tian, Feng; Wei, Ji-Chao; Tai, Ming-Hui; Meng, Fan-Di

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자료유형: 학술저널

저자정보: Qu, Kai (Department of Hepatobiliary Surgery, The First Affiliated Hospital of Medical College, Xi'an Jiaotong University) Liu, Si-Nan (Department of Hepatobiliary Surgery, The First Affiliated Hospital of Medical College, Xi'an Jiaotong University) Chang, Hu-Lin (Department of Hepatobiliary Surgery, The First Affiliated Hospital of Medical College, Xi'an Jiaotong University) Liu, Chang (Department of Hepatobiliary Surgery, The First Affiliated Hospital of Medical College, Xi'an Jiaotong University) Xu, Xin-Sen (Department of Hepatobiliary Surgery, The First Affiliated Hospital of Medical College, Xi'an Jiaotong University) Wang, Rui-Tao (Department of Hepatobiliary Surgery, The First Affiliated Hospital of Medical College, Xi'an Jiaotong University) Zhou, Lei (Department of Hepatobiliary Surgery, The First Affiliated Hospital of Medical College, Xi'an Jiaotong University) Tian, Feng (Department of Hepatobiliary Surgery, The First Affiliated Hospital of Medical College, Xi'an Jiaotong University) Wei, Ji-Chao (Department of Hepatobiliary Surgery, The First Affiliated Hospital of Medical Co) Tai, Ming-Hui Meng, Fan-Di

저널정보: 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제13권 제4호

발행연도: 2012.1

수록면: 1,317 - 1,320 (4page)

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Biliary tract cancers, broadly described as malignancies that arise from the biliary tract epithelia, are usually divided into two major clinical phenotypes: cholangiocarcinoma and gallbladder cancer, differing in etiopathogenesis, risk factors, and perhaps molecular and genetic signatures. Atypical symptoms and lack of tumor biomarkers make it difficult to diagnose in early stages. At the time of presentation, few patients are candidates for potentially curative surgical resection. We here assessed and compared features of a total of 150 cases divided into extra- and intrahepatic cholangiocarcinomas and gallbladder cancers (GBC). Althought there were no significant differences in serum tumour marker levels, GBC patients had the poorest prognosis. Furthermore, gallbladder cancer respond poorly to chemotherapy or radiation therapy and approximately half of untreated patients died within 10 months. Therefore, treatment for patients with gallbladder cancer is still in challenge. Outcomes and survival of these patients had improved little over the past three decades - a period in which new successful treatments have greatly contributed to the prolonged patient survival for many other cancers.

#Gallbladder cancer #biliary tract cancer #epidemiology #treatment #China

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Qu, Kai

소속기관 Department of Hepatobiliary Surgery, The First Affiliated Hospital of Xi'an Jiaotong University