Lymphoproliferative Disorders in Multiple Primary Cancers

Demirci, Umut; Ozdemir, Nuriye; Benekli, Mustafa; Babacan, Nalan Akgul; Cetin, Bulent; Baykara, Meltem; Coskun, Ugur; Zengin, Nurullah; Buyukberber, Suleyman

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자료유형: 학술저널

저자정보: Demirci, Umut (Ataturk Education and Research Hospital, Gazi University) Ozdemir, Nuriye (Numune Education and Research Hospital, Department of Medical Oncology, Gazi University) Benekli, Mustafa (Faculty of Medicine, Department of Medical Oncology, Gazi University) Babacan, Nalan Akgul (Numune Education and Research Hospital, Department of Medical Oncology, Gazi University) Cetin, Bulent (Faculty of Medicine, Department of Medical Oncology, Gazi University) Baykara, Meltem (Faculty of Medicine, Department of Medical Oncology, Gazi University) Coskun, Ugur (Faculty of Medicine, Department of Medical Oncology, Gazi University) Zengin, Nurullah (Numune Education and Research Hospital, Department of Medical Oncology, Gazi University) Buyukberber, Suleyman (Faculty of Medicine, Department of Medical Oncology, Gazi University)

저널정보: 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제13권 제1호

발행연도: 2012.1

수록면: 383 - 386 (4page)

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Background: Cancer survivors are at increased risk of second cancers. Lymphoproliferative disorders (LPD) are common neoplasms that are primary or subsequent cancers in cases of multiple primary cancer. We here analyzed metachronous or synchronous LPD in multiple primary cancers. Methods: Between 2001 and 2010, LPD were assessed retrospectively in 242 multiple primary cancers patients. Results: Forty nine (20.2%) patients with LPD were detected. Six patients had two LPD where one patient had three LPD. The median age of patients was 60.5 years (range: 28-81). LPD were diagnosed in 29 patients as primary cancer, in 23 patients as second cancer, and in three patients as third cancer in multiple primary cancers. Primary tumor median age was 56 (range: 20-79). Diffuse large B cell lymphoma (n=16), breast cancer (n=9), and lung cancer (n=6) were detected as subsequent cancers. Alklylating agents were used in 19 patients (43.2%) and 20 patients (45.5%) had received radiotherapy for primary cancer treatment. The median follow-up was 70 months (range: 7-284). Second malignancies were detected after a median of 51 months (range: 7-278), and third malignancies with a median of 18 months (range: 6-72). Conclusions: In this study, although breast and lung cancer were the most frequent detected solid cancers in LPD survivors, diffuse large B cell lymphoma was the most frequent detected LPD in multiple primary cancers.

#Multiple primary cancers #lymphoproliferative disorders #diffuse large B cell lymphoma

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