Hypersensitivity Reactions to Oxaliplatin: Clinical Features and Risk Factors in Koreans

Kim, Mi-Yeong; Kang, Sung-Yoon; Lee, Suh-Young; Yang, Min-Suk; Kim, Min-Hye; Song, Woo-Jung; Kim, Sae-Hoon; Kim, Yo-Jung; Lee, Keun-Wook; Cho, Sang-Heon; Min, Kyung-Up; Lee, Jong-Seok; Kim, Jee-Hyun; Chang, Yoon-Seok

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자료유형: 학술저널

저자정보: Kim, Mi-Yeong (Department of Internal Medicine, Seoul National University College of Medicine) Kang, Sung-Yoon (Department of Internal Medicine, Seoul National University College of Medicine) Lee, Suh-Young (Department of Internal Medicine, Seoul National University College of Medicine) Yang, Min-Suk (Department of Internal Medicine, Seoul National University College of Medicine) Kim, Min-Hye (Department of Internal Medicine, Seoul National University College of Medicine) Song, Woo-Jung (Department of Internal Medicine, Seoul National University College of Medicine) Kim, Sae-Hoon (Department of Internal Medicine, Seoul National University College of Medicine) Kim, Yo-Jung (Department of Internal Medicine, Seoul National University College of Medicine) Lee, Keun-Wook (Department of Internal Medicine, Seoul National University College of Medicine) Cho, Sang-Heon (Department of Internal Medicine, Seoul National University College of Medicine) Min, Kyung-Up (Department of Internal Medicine, Seoul National University College of Medicine) Lee, Jong-Seok (Department of Internal Medicine, Seoul National University College of Medicine) Kim, Jee-Hyun (Department of Internal Medic) Chang, Yoon-Seok

저널정보: 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제13권 제4호

발행연도: 2012.1

수록면: 1,209 - 1,215 (7page)

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Background and Aim: Oxaliplatin hypersensitivity is a well-known adverse reaction but the prevalence varies and data for frequency and clinical features have not been reported for Korea. Here we evaluates the prevalence and risk factors for hypersensitivity reactions to oxaliplatin after chemotherapy. Methods: Clinical information on all patients treated with oxaliplatin was retrospectively reviewed in electronic medical records between August 2009 and July 2010 in Seoul National University Bundang Hospital. Patients who experienced hypersensitivity reactions to oxaliplatin were compared with those who did not. Results: A total of 393 patients received oxaliplatin, with 42 (10.7%) experiencing hypersensitivity reactions including three cases of anaphylaxis. Median cycle of the first hypersensitivity reaction was 8. Reactions correlated with lower dexamethasone doses. Other variables were not significant. Conclusions: The prevalence of hypersensitivity reactions was 10.7%, symptoms being mostly mild and cutaneous. Lower dexamethasone doses could be a predictor for hypersensitivity reactions to oxaliplatin.

#Oxaliplatin #hypersensitivity #drug hypersensitivity #electronic health records

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