Clinical Outcomes of Cases with Absent Cervical Dysplasia in Cold Knife Conization Specimens

Baser, Eralp; Ozgu, Emre; Erkilinc, Selcuk; Yalcin, Hakan; Cetinkaya, Nilufer; Sirvan, Levent; Erkaya, Salim; Gungor, Tayfun

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자료유형: 학술저널

저자정보: Baser, Eralp (Department of Gynecologic Oncology, Zekai Tahir Burak Women's Health Education and Research Hospital) Ozgu, Emre (Department of Gynecologic Oncology, Zekai Tahir Burak Women's Health Education and Research Hospital) Erkilinc, Selcuk (Department of Obstetrics and Gynecology, Zekai Tahir Burak Women's Health Education and Research Hospital) Yalcin, Hakan (Department of Gynecologic Oncology, Zekai Tahir Burak Women's Health Education and Research Hospital) Cetinkaya, Nilufer (Department of Gynecologic Oncology, Zekai Tahir Burak Women's Health Education and Research Hospital) Sirvan, Levent (Department of Pathology, Zekai Tahir Burak Women's Health Education and Research Hospital) Erkaya, Salim (Department of Obstetrics and Gynecology, Zekai Tahir Burak Women's Health Education and Research Hospital) Gungor, Tayfun (Department of Gynecologic Oncology, Zekai Tahir Burak Women's Health Education and Research Hospital)

저널정보: 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제14권 제11호

발행연도: 2013.1

수록면: 6,693 - 6,696 (4page)

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Background: Cold knife conization is a surgical procedure that allows both diagnosis and treatment of cervical lesions at the same time. It is mainly performed for indications of high-grade cervical intraepithelial neoplasia (CIN). In this study, we aimed to investigate the clinical outcome of cases without CIN in cold knife conization specimen, following a high-grade lesion (CIN2/3) in cervical biopsy. Materials and Methods: We performed a retrospective cohort study at a tertiary referral hospital between January $1^{st}$ 2008 and August $1^{st}$ 2012. Cases that underwent cold knife conization for CIN2/3 within the study period were included. Cone-negative (Group 1) and cone-positive (Group 2) cases were analyzed for various clinical parameters, and were compared in the 1-year post-conization period for histological recurrence and human papillomavirus (HPV) DNA status. Results: A total of 173 women underwent cold knife conization for CIN2/3 within the study period. Twenty-two cases (12.7%) were included in Group 1 and 151 cases (87.3%) in Group 2. There were no significant differences between the two groups in terms of age, gravidity, parity, menopausal status and HPV-DNA status (pre-conization and 1 year post-conization) (p>0.05). Recurrence rates were also similar between the groups (9.1% vs 9.9%, p>0.05). Conclusions: Clinical outcomes were similar in terms of histological recurrence and HPV persistence after 1 year of follow-up between cone-negative and cone-positive cases. Clinical follow-up of cone-negative cases should therefore be performed similar to cone-positive cases.

#Cold knife conization #human papillomavirus #cervical intraepithelial neoplasia

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Baser, Eralp

소속기관 Obstetrics and Gynecology Department of Zekai Tahir Burak Women's Health and Research Hospital