Prevalence and Genotype Distribution of Human Papillomavirus Infections in Women Attending Hospitals in Chaozhou of Guangdong Province

Chen, Qiang; Luo, Zhao-Yun; Lin, Min; Lin, Qi-Li; Chen, Chan-Yu; Yang, Chun; Xie, Long-Xu; Li, Hui; Zheng, Jia-Kun; Yang, Li-Ye; Ju, Gui-Zhi

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저자정보: Chen, Qiang (Department of Radiobiology, School of Public Health, Jilin University) Luo, Zhao-Yun (Laboratory Medical Center, Chaozhou Central Hospital) Lin, Min (Laboratory Medical Center, Chaozhou Central Hospital) Lin, Qi-Li (Department of Gynecology and Obstetrics, Chaozhou People's Hospital) Chen, Chan-Yu (Department of Gynecology, Chaozhou Central Hospital) Yang, Chun (Department of Gynecology, Chaozhou Central Hospital) Xie, Long-Xu (Hybribio Limited Corporation) Li, Hui (Department of Gynecology and Obstetrics, Chaozhou Gynecological and Pediatric Hospital) Zheng, Jia-Kun (Laboratory Medical Center, Chaozhou Central Hospital) Yang, Li-Ye (Laboratory Medical Center, Chaozhou Central Hospital) Ju, Gui-Zhi (Department of Radiobiology, School of Public Health, Jilin University)

저널정보: 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제13권 제4호

발행연도: 2012.1

수록면: 1,519 - 1,524 (6page)

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Background: Human papillomavirus (HPV) infection is the main cause of cervical cancer. Limited epidemiologic data of HPV prevalence are available for women attending hospitals in southern China. This study aimed to evaluate the profiles of HPV infection and cytology status in gynecological outpatients in Chaozhou City. Methods: A total of 2833 eligible women were enrolled. The HPV GenoArray test was used for HPV detection and genotyping. Nearly one half of the HPV positive women received liquid-based cytology test. Logistic regression analysis was performed to assess the predictable effects of age and genotype for categories of abnormal cytology. Results: The prevalence of overall, high-risk, and low-risk HPV infection were 24.5%, 19.5% and 8.4%, respectively. A U-shaped age-specific prevalence curve was observed in overall HPV and high-risk HPV, but not in low-risk HPV, which declined with age increasing. The 6 most common high-risk HPV type in descending order, were types 52, 16, 58, 18, 68, and 33. Age and HPV genotype were both important determinants of abnormal cytology incidence, the older women (>45 years) and those infected with HPV type 16 and/or 18 having the highest risk for abnormal cytology. Conclusion: Our findings support the hypothesis that second-generation HPV prophylactic vaccines including HPV-52 and -58 may offer higher protection for women residing in Chaozhou and neighboring cities in Guangdong.

#Human papillomavirus #prevalence #outpatients #Guangdong, China

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