Long-Term Outcomes of Adult Lung Transplantation Recipients: A Single-Center Experience in South Korea

Jo, Kyung-Wook; Hong, Sang-Bum; Kim, Dong Kwan; Jung, Sung Ho; Kim, Hyeong Ryul; Choi, Se Hoon; Lee, Geun Dong; Lee, Sang-Oh; Do, Kyung-Hyun; Chae, Eun Jin; Choi, In-Cheol; Choi, Dae-Kee; Kim, In Ok; Park, Seung-Il; Shim, Tae Sun

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자료유형: 학술저널

저자정보: Jo, Kyung-Wook (Division of Pulmonology and Critical Care Medicine, Asan Medical Center, University of Ulsan College of Medicine) Hong, Sang-Bum (Division of Pulmonology and Critical Care Medicine, Asan Medical Center, University of Ulsan College of Medicine) Kim, Dong Kwan (Department of Thoracic and Cardiovascular Surgery, Asan Medical Center, University of Ulsan College of Medicine) Jung, Sung Ho (Department of Thoracic and Cardiovascular Surgery, Asan Medical Center, University of Ulsan College of Medicine) Kim, Hyeong Ryul (Department of Thoracic and Cardiovascular Surgery, Asan Medical Center, University of Ulsan College of Medicine) Choi, Se Hoon (Department of Thoracic and Cardiovascular Surgery, Asan Medical Center, University of Ulsan College of Medicine) Lee, Geun Dong (Department of Thoracic and Cardiovascular Surgery, Asan Medical Center, University of Ulsan College of Medicine) Lee, Sang-Oh (Department of Infectious Diseases, Asan Medical Center, University of Ulsan College of Medicine) Do, Kyung-Hyun (Department of Radiology, Asan Medical Center, University of Ulsan College of Medicine) Chae, Eun Jin (Department of) Choi, In-Cheol Choi, Dae-Kee Kim, In Ok Park, Seung-Il Shim, Tae Sun

저널정보: 대한결핵 및 호흡기학회 Tuberculosis and Respiratory Diseases 결핵 및 호흡기 질환 제82권 제4호

발행연도: 2019.1

수록면: 348 - 356 (9page)

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Background: Recently, the number of lung transplants in South Korea has increased. However, the long-term outcome data is limited. In this study, we aimed to investigate the long-term outcomes of adult lung transplantation recipients. Methods: Among the patients that underwent lung transplantation at a tertiary referral center in South Korea between 2008 and 2017, adults patient who underwent deceased-donor lung transplantation with available follow-up data were enrolled. Their medical records were retrospectively reviewed. Results: Through eligibility screening, we identified 60 adult patients that underwent lung (n=51) or heart-lung transplantation (n=9) during the observation period. Idiopathic pulmonary fibrosis (46.7%, 28/60) was the most frequent cause of lung transplantation. For all the 60 patients, the median follow-up duration for post-transplantation was 2.6 years (range, 0.01-7.6). During the post-transplantation follow-up period, 19 patients (31.7%) died at a median duration of 194 days. The survival rates were 75.5%, 67.6%, and 61.8% at 1 year, 3 years, and 5 years, respectively. Out of the 60 patients, 8 (13.3%) were diagnosed with chronic lung allograft dysfunction (CLAD), after a mean duration of $3.3{\pm}2.8years$ post-transplantation. The CLAD development rate was 0%, 17.7%, and 25.8% at 1 year, 3 years, and 5 years, respectively. The most common newly developed post-transplantation comorbidity was the chronic kidney disease (CKD; 54.0%), followed by diabetes mellitus (25.9%). Conclusion: Among the adult lung transplantation recipients at a South Korea tertiary referral center, the long-term survival rates were favorable. The proportion of patients who developed CLAD was not substantial. CKD was the most common post-transplantation comorbidity.

#Lung Transplantation #Survival #Chronic Lung Allograft Dysfunction #Chronic Kidney Disease

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Jo, Kyung-Wook

소속기관 Department of Pulmonary and Critical Care Medicine, Asan Medical Center, University of Ulsan College

주요연구분야 의약학 > 임상의학 > 내과학

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Hong, Sang-Bum

소속기관 Division of Pulmonology and Critical Care Medicine, Asan Medical Center, University of Ulsan College

주요연구분야 의약학 > 임상의학 > 내과학

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Kim, Dong Kwan