Effects of Age, Breast Density and Volume on Breast Cancer Diagnosis: A Retrospective Comparison of Sensitivity of Mammography and Ultrasonography in China's Rural Areas

Wang, Feng-Liang; Chen, Fei; Yin, Hong; Xu, Nan; Wu, Xiao-Xiang; Ma, Jing-Jing; Gao, Shen; Tang, Jin-Hai; Lu, Cheng

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자료유형: 학술저널

저자정보: Wang, Feng-Liang (Department of Breast Surgery, Nanjing Maternity and Child Health Care Hospital, Nanjing Medical University) Chen, Fei (Department of Breast Surgery, Nanjing Maternity and Child Health Care Hospital, Nanjing Medical University) Yin, Hong (Department of Breast Surgery, Nanjing Maternity and Child Health Care Hospital, Nanjing Medical University) Xu, Nan (First Clinical Medicine College, Nanjing University of Chinese Medicine) Wu, Xiao-Xiang (Department of Breast Surgery, Nanjing Maternity and Child Health Care Hospital, Nanjing Medical University) Ma, Jing-Jing (Department of Breast Surgery, Nanjing Maternity and Child Health Care Hospital, Nanjing Medical University) Gao, Shen (Department of Breast Surgery, Nanjing Maternity and Child Health Care Hospital, Nanjing Medical University) Tang, Jin-Hai (Department of Breast Surgery, Jiangsu Cancer Hospital and Research Institute) Lu, Cheng (Department of Breast Surgery, Nanjing Maternity and Child Health Care Hospital, Nanjing Medical University)

저널정보: 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제14권 제4호

발행연도: 2013.1

수록면: 2,277 - 2,282 (6page)

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Purpose: Mammography has been confirmed as the only effective mode to improve the prognosis of patients with breast cancer in Western developed countries, but might not be a good choice in other areas of the world. One of the major challenges in China is to determine an optimal imaging modality for breast cancer screening. This study was designed to clarify the sensitivity of ultrasonography compared with that of mammography in rural China. Methods: We retrospectively studied the sensitivity of mammography and ultrasonography based on 306 breast cancer patients detected by the program of "screening for cervical cancer and breast cancer" performed in Chinese rural areas between January 2009 and December 2011, and analyzed the effects of age, breast density and volume on the sensitivity. Results: Stratified analysis showed that the sensitivity of breast ultrasonography was significantly higher than that of mammography in premenopausal patients (81.4% vs. 61.1%, p=0.02), in women ${\leq}$ 55 years of age (82.2% vs. 63.4%, p<0.01), in the high breast density group (American College of Radiology [ACR] levels 3-4) (85.9% vs. 60.6%, p<0.01) and in the small breast volume group (${\leq}$ 400 ml) (87.1% vs. 66.7%, p<0.01). Age had a significant effect on sensitivity of mammography (breast density and volume-adjusted odds ratio, 6.39; 95% confidence interval, 2.8-14.4 in age group > 55 compared to age group ${\leq}$ 45), but not that of ultrasonography. Neither breast density nor volume had significant effect on sensitivity of mammography or ultrasonography. Conclusions: Ultrasonography is more sensitive than mammography in detecting breast cancer in women under 55 year-old Chinese, especially in those with high-density and relatively small breasts.

#Breast cancer screening #mammography #ultrasonography #sensitivity #rural China

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Wang, Feng-Liang

소속기관 Department of Breast Surgery, Nanjing Maternity and Child Health Care Hospital, Nanjing Medical Univ