Comparison of Diagnostic Accuracies of Serum HE-4 Levels and 3D Power Doppler Angiography Parameters between Benign Endometrial Pathologies and Endometrial Cancer

Erenel, Hakan; Bese, Tugan; Sal, Veysel; Demirkiran, Fuat; Arvas, Macit

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저자정보: Erenel, Hakan (Department of Obstetrics and Gynecology, Sisli Hamidiye Etfal Training and Research Hospital) Bese, Tugan (Department of Obstetrics and Gynecology, Sisli Hamidiye Etfal Training and Research Hospital) Sal, Veysel (Department of Obstetrics and Gynecology, Sisli Hamidiye Etfal Training and Research Hospital) Demirkiran, Fuat (Department of Obstetrics and Gynecology, Sisli Hamidiye Etfal Training and Research Hospital) Arvas, Macit (Department of Obstetrics and Gynecology, Sisli Hamidiye Etfal Training and Research Hospital)

저널정보: 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제17권 제5호

발행연도: 2016.1

수록면: 2,507 - 2,511 (5page)

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Purpose: To study the diagnostic accuracies of serum human epididymis protein 4 (HE-4) levels, virtual organ computer-aided analysis (VOCAL) parameters and endometrial volume in endometrial cancer cases. Materials and Methods: One hundred and seven patients (37 with endometrial cancer and 70 with benign endometrial pathology) were included in this study. VOCAL parameters and serum HE-4 levels were compared between the groups. Results: Area under the curve (AUC) values were 0.702, 0.658, 0.706 for vascularization index (VI), the flow index (FI) and the vascularization flow index (VFI), respectively. A cut off value of 0.568 for VI demonstrated 70% sensitivity, 72% specificity, 56% positive predictive value (PPV) and a81% negative predictive value (NPV). A cut off value of 25.8 for showed a senitivith of 70% and a specificity of 58% with aPPV of 46% and NPV of 78%, and with a cut off value of 0.12 for VFI 70%, 69%, 54% and 81%, respectively. The area under the curve for HE-4 was 0.814. A cut off value of 458 pmol/L was predictive of malignancy with 86% sensitivity and 63% specificity. Conclusions: VOCAL parameters and serum HE-4 levels were statistically significantly higher in the endometrial cancer patients. Serum HE-4 levels provided a greater sensitivity compared to power doppler angiography for predicting malignancy or benign endometrial pathology.

#Endometrial cancer #colour doppler #HE-4 protein #three-dimensional #ultrasonography

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Erenel, Hakan

소속기관 Department of Obstetrics and Gynecology, Sisli Hamidiye Etfal Training and Research Hospital