Intra-operative Rectal Washout with Saline Solution Can Effectively Prevent Anastomotic Recurrence: a Meta-analysis

Zhou, Can; Ren, Yu; Wang, Ke; Liu, Jie; He, Jian-Jun; Liu, Pei-Jun

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저자정보: Zhou, Can (Department of Centre of Translational Medicine, the First Affiliated Hospital of Xi'an Jiaotong University) Ren, Yu (Department of Surgical Oncology, the First Affiliated Hospital of Xi'an Jiaotong University) Wang, Ke (Department of Surgical Oncology, the First Affiliated Hospital of Xi'an Jiaotong University) Liu, Jie (Department of Centre of Translational Medicine, the First Affiliated Hospital of Xi'an Jiaotong University) He, Jian-Jun (Department of Surgical Oncology, the First Affiliated Hospital of Xi'an Jiaotong University) Liu, Pei-Jun (Department of Centre of Translational Medicine, the First Affiliated Hospital of Xi'an Jiaotong University)

저널정보: 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제14권 제12호

발행연도: 2013.1

수록면: 7,155 - 7,159 (5page)

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Background and Objective: Rectal washout with saline solution may theoretically prevent anastomotic recurrence in patients with resectable rectal cancer, although exact clinical effects have not yet been determined. In order to derive a more precise estimation of the relationship, the present meta-analysis was performed. Method: Relevant studies were identified by a search of Medline, Embase and Google Website with no restrictions to September 1, 2013, and included in the systematic review and meta-analysis. Results: 5 trials (642 participants) were included to assess the association between rectal washout with saline solution and anastomotic recurrence. The rate of anastomotic recurrence (AR) was 6.23% (40/642), with the pooled OR derived from the five studies being 0.32 (95 % CI=0.15-0.70, P=0.004). The pooled OR derived from the TME and radical resection subgroups were 0.72 (95%CI=0.16-3.12, P=0.66) and 0.51 (95%CI=0.13-1.96, P=0.32), respectively. Conclusion: Results from this analysis show that intra-operative rectal washout with mere saline solution largely reduces the risk of anastomotic recurrences in patients with resectable rectal cancer.

#Rectal cancer #rectal washout #anastomotic recurrence #prevention #meta-analysis

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Zhou, Can

소속기관 Department of Centre of Translational Medicine, the First Affiliated Hospital of Xi'an Jiaotong Univ