Effects of Allogeneic Blood Transfusion in Patients with Stage II Colon Cancer

Meng, Jin; Lu, Xiao-Bo; Tang, Yuan-Xin; Sun, Gong-Ping; Li, Xin; Yan, Yi-Fei; Liang, Gao-Feng; Ma, Si-Ping; Li, Xiao-Xia

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자료유형: 학술저널

저자정보: Meng, Jin (Department of Gastrointestinal Surgery, The Fourth Affiliated Hospital, China Medical University) Lu, Xiao-Bo (Department of Toxicology, Public Health School, China Medical University) Tang, Yuan-Xin (Department of Gastrointestinal Surgery, The Fourth Affiliated Hospital, China Medical University) Sun, Gong-Ping (Department of Gastrointestinal Surgery, The Fourth Affiliated Hospital, China Medical University) Li, Xin (Department of Gastrointestinal Surgery, The Fourth Affiliated Hospital, China Medical University) Yan, Yi-Fei (Department of Gastrointestinal Surgery, The Fourth Affiliated Hospital, China Medical University) Liang, Gao-Feng (Department of Gastrointestinal Surgery, The Fourth Affiliated Hospital, China Medical University) Ma, Si-Ping (Department of Colorectal Surgery, Liaoning Province Tumor Hospital) Li, Xiao-Xia (Department of Gastrointestinal Surgery, The Fourth Affiliated Hospital, China Medical University)

저널정보: 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제14권 제1호

발행연도: 2013.1

수록면: 347 - 350 (4page)

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The aim of the present study was to determine whether allogeneic red blood cell transfusions showed a deleterious effect and what might be preoperative risk factors for blood transfusion in patients with TNM stage II colon cancer. Total 470 patients who fulfilled inclusion criteria were selected for a further 10-year follow-up study. We found that there were statistical significance between non-transfused and transfused group in mortality (P=0.018), local recurrence (P=0.000) and distant metastasis (P=0.040). Local recurrence and distant metastasis between 1 to 3 units and more than 3 units group did not show any significant differences. There was no difference in survival rate between non-transfused and 1 to 3 units group (log rank=0.031, P=0.860). The difference between different blood transfusion volume in transfused patients was found (78.77% vs 63.83%, P=0.006). Meanwhile, the significant difference of survival rate was existed between non-transfused group and more than 3 units group (84.83% vs 63.83%, P=0.002 ). Univariate analysis showed the following 3 variables to be associated with an increased risk of allogeneic blood transfusions: preoperative CEA level (P<0.05), location of tumor (P<0.01) and diameter of tumor (P<0.01). Multivariate analysis revealed that location of tumor and diameter of tumor are two independent factors for requirement of perioperative transfusions. Therefore, allogeneic transfusion increase the postoperative tumor mortality, local recurrence and distant metastasis in patients with stage II colon cancer. The postoperative tumor mortality, local recurrence and distant metastasis were not associated with the blood transfusion volume. The blood transfusion volume was associated with the survival rate. Location of tumor and diameter of tumor were the independent preoperative risk factors for blood transfusion.

#Colon cancer #blood transfusion #local recurrence #distant metastasis

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Meng, Jin

소속기관 Department of Gastrointestinal Surgery, The Fourth Affiliated Hospital, China Medical University