Impact of Treatment Strategies on Local Control and Survival in Uterine Carcinosarcomas in Turkey

Kucukoztas, Nadire; Dizdar, Omer; Rahatli, Samed; Dursun, Polat; Yalcin, Selim; Altundag, Ozden; Ozen, Ozlem; Reyhan, Nihan Haberal; Tarhan, Cagla; Yildiz, Ferah; Ayhan, Ali

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자료유형: 학술저널

저자정보: Kucukoztas, Nadire (Department of Medical Oncology, Baskent University Hospital) Dizdar, Omer (Department of Medical Oncology, Baskent University Hospital) Rahatli, Samed (Department of Medical Oncology, Baskent University Hospital) Dursun, Polat (Department of Obstetrics and Gynecology, Baskent University Hospital) Yalcin, Selim (Department of Medical Oncology, Baskent University Hospital) Altundag, Ozden (Department of Medical Oncology, Baskent University Hospital) Ozen, Ozlem (Department of Pathology, Baskent University Hospital) Reyhan, Nihan Haberal (Department of Pathology, Baskent University Hospital) Tarhan, Cagla (Department of Radiology, Baskent University Hospital) Yildiz, Ferah (Department of Radiation Oncology, Hacettepe University Institute of Oncology) Ayhan, Ali (Department of Obstetrics and Gynecology, Baskent University Hospital)

저널정보: 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제14권 제5호

발행연도: 2013.1

수록면: 2,959 - 2,962 (4page)

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Background: The purpose of this study was to determine the clinical characteristics, patterns of recurrence and survival outcomes in patients with uterine carcinosarcomas treated in our institution. Materials and Methods: Records of 26 patients diagnosed between 2007 and 2011 with uterine carcinosarcoma were retrospectively evaluated for demographic features, tumor characteristics, treatment regimens and patient outcomes in terms of DFS and OS Results: Median age was 61 (range 43-78). 10 patients (38%) had stage I disease at diagnosis, 3 (12%) had stage II, 4 (15%) had stage III and 9 (35%) had stage IV. Sixteen patients (62%) received chemotherapy with paclitaxel and carboplatin for 6 cycles. One patient underwent radiotherapy. Median follow up was 17 months. Sixteen patients relapsed and 13 died during follow up. Considering recurrence, 5 out of 16 patients had lung metastases, one had brain metastases and 9 had only intraabdominal recurrence. The 3 year DFS was 37% and the 3 year OS was 30%. Conclusions: Our data show that uterine carcinosarcomas tend to be at advanced stage at diagnosis and despite the use of chemotherapy, overall prognosis is poor. Surgery remains the mainstay of treatment. More effective adjuvant strategies are needed to reduce relapse and death rates.

#Uterine carcinosarcoma #treatment #survival #Turkey

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