Somatic Mutations of K-Ras and BRAF in Thai Colorectal Cancer and their Prognostic Value

Chaiyapan, Welawee; Duangpakdee, Pongsanae; Boonpipattanapong, Teeranut; Kanngern, Samornmas; Sangkhathat, Surasak

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저자정보: Chaiyapan, Welawee (Tumor Biology Research Unit, Department of Surgery, Faculty of Medicine, Prince of Songkla University) Duangpakdee, Pongsanae (Tumor Biology Research Unit, Department of Surgery, Faculty of Medicine, Prince of Songkla University) Boonpipattanapong, Teeranut (Tumor Biology Research Unit, Department of Surgery, Faculty of Medicine, Prince of Songkla University) Kanngern, Samornmas (Tumor Biology Research Unit, Department of Surgery, Faculty of Medicine, Prince of Songkla University) Sangkhathat, Surasak (Tumor Biology Research Unit, Department of Surgery, Faculty of Medicine, Prince of Songkla University)

저널정보: 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제14권 제1호

발행연도: 2013.1

수록면: 329 - 332 (4page)

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Background: The study aimed to determine the incidence of K-ras and BRAF mutations in colorectal cancers (CRCs) in Thai patients and evaluate association with clinicopathological parameters including treatment outcomes in terms of event free survival (EFS). Materials and Methods: Two-hundred colorectal cancer specimens were collected for studies of K-Ras codon 12, 13 and 61, and BRAF codon 600 by polymerase chain reaction and direct nucleotide sequencing. Results: The overall incidence of K-Ras mutations in our patients was 23%. K-ras mutation frequencies in CRC stages (AJCC) I, II, III and IV were 6.7%, 16.1%, 23.3% and 26.6%, respectively (p-value>0.05). The three most common mutation forms were G12D, G12V and G13D. K-Ras mutation status was associated with poorer EFS in stage I-III CRCs (p-value 0.03). Conclusions: The study found a lower mutation frequency of K-Ras and BRAF compared to reports involving other ethnic groups. However, K-Ras mutations did have a negative prognostic value in early-stage CRCs.

#Colorectal cancer #K-Ras #BRAF #prognostic significance

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Chaiyapan, Welawee

소속기관 Tumor Biology Research Unit, Department of Surgery, Faculty of Medicine, Prince of Songkla Universit