Expression and Significance of Hypoxia Inducible Factor-1α and Lysyl Oxidase in Non-small Cell Lung Cancer

Ping, Wei; Jiang, Wen-Yang; Chen, Wen-Shu; Sun, Wei; Fu, Xiang-Ning

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저자정보: Ping, Wei (Department of Thoracic Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology) Jiang, Wen-Yang (Department of Thoracic Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology) Chen, Wen-Shu (Department of Thoracic Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology) Sun, Wei (Department of Thoracic Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology) Fu, Xiang-Ning (Department of Thoracic Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology)

저널정보: 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제14권 제6호

발행연도: 2013.1

수록면: 3,613 - 3,618 (6page)

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Object: To detect expression of hypoxia inducible factor-$1{\alpha}$ (HIF-$1{\alpha}$) and lysyl oxidase (LOX) in non-small cell lung cancer (NSCLC) and explore their roles in prognosis. Methods: The mRNA levels of HIF-$1{\alpha}$ and LOX were investigated by real-time reverse-transcriptase polymerase chain reaction in 40 cases of tumour and paired normal tissues. In addition, protein expression of HIF-$1{\alpha}$ and LOX was examined by immunohistochemistry in 82 cases of tumour and 45 paired normal tissues. The relationship between HIF-$1{\alpha}$ or LOX and clinicopathologic characteristics, as well as the correlation between HIF-$1{\alpha}$ and LOX, were also examined. Kaplan-Meier survival curves and the log-rank test were used to analyze progression-free survival. Results: HIF-$1{\alpha}$ or LOX mRNA levels in tumor tissues was significantly higher than those in paired normal tissues (p<0.01). Positive HIF-$1{\alpha}$ or LOX protein expression in tumor tissues was noted in 46/82 (56.1%) and 49/82 (59.8%) of the cases, respectively, being significantly higher than those in paired normal tissues (p<0.05). There was significant correlation between the expression of HIF-$1{\alpha}$ or LOX and tumor size, lymph node metastasis and pathological stage (p<0.05). The expression of HIF-$1{\alpha}$ and LOX had a significant inverse impact on survival of patients with NSCLC. Conclusion: HIF-$1{\alpha}$ and LOX may play a pivotal role in the development of NSCLC, and may act in synergy to promote the progression of NSCLC.

#HIF- $1{a lpha}$ #LOX #NSCLC #prognosis

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Ping, Wei

소속기관 Department of Thoracic Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Scie