Prognostic Value of Lymph Node Ratios in Node Positive Rectal Cancer Treated with Preoperative Chemoradiation

Nadoshan, Jamal Jafari; Omranipour, Ramesh; Beiki, Omid; Zendedel, Kazem; Alibakhshi, Abbas; Mahmoodzadeh, Habibollah

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자료유형: 학술저널

저자정보: Nadoshan, Jamal Jafari (Department of Surgical Oncology, Cancer Institute, Tehran University of Medical Science) Omranipour, Ramesh (Department of Surgical Oncology, Cancer Institute, Tehran University of Medical Science) Beiki, Omid (Kermanshah University of Medical Sciences) Zendedel, Kazem (Cancer Research Center, Cancer Institute, Tehran University of Medical Science) Alibakhshi, Abbas (Department of Surgical Oncology, Cancer Institute, Tehran University of Medical Science) Mahmoodzadeh, Habibollah (Department of Surgical Oncology, Cancer Institute, Tehran University of Medical Science)

저널정보: 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제14권 제6호

발행연도: 2013.1

수록면: 3,769 - 3,772 (4page)

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Background: To investigate the impact of the lymph node ratio (LNR) on the prognosis of patients with locally advanced rectal cancer undergoing pre-operative chemoradiation. Methods: Clinicopathologic and follow up data of 128 patients with stage III rectal cancer who underwent curative resection from 1996 to 2007 were reviewed. The patients were divided into two groups according to the lymph node ratio: LNR ${\leq}$ 0.2 (n=28), and >0.2 (n=100). Kaplan-Meier and the Cox proportional hazard regression models were used to evaluate the prognostic effects according to LNR. Results: Median numbers of lymph nodes examined and lymph nodes involved by tumour were 10.3 (range 2-28) and 5.8 (range 1-25), respectively, and the median LNR was 0.5 (range, 0-1.6). The 5-year survival rate significantly differed by LNR (${\leq}$ 0.2, 69%; >0.2, 19%; Log-rank p value < 0.001). LNR was also a significant prognostic factor of survival adjusted for age, sex, post-operative chemotherapy, total number of examined lymph nodes, metastasis and local recurrence (${\leq}$ 0.2, HR=1; >0.2, HR=4.8, 95%CI=2.1-11.1) and a significant predictor of local recurrence and distant metastasis during follow-up independently of total number of examined lymph node. Conclusions: Total number of examined lymph nodes and LNR were significant prognostic factors for survival in patients with stage III rectal cancer undergoing pre-operative chemoradiotherapy.

#Node ratio #rectal cancer #prognosis #preoperative chemoradiation

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