Clinical Analysis of Stages of HBV Infection in 100 Cases of Lymphoma

Tang, Yang; Sun, Li-Guang; Liu, Chun-Shui; Li, Yu-Ying; Jin, Chun-Hui; Li, Dan; Bai, Ou

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자료유형: 학술저널

저자정보: Tang, Yang (Department of Oncology, the First Hospital of Jilin University) Sun, Li-Guang (School of Translational Medicine, the First Hospital of Jilin University) Liu, Chun-Shui (Department of Oncology, the First Hospital of Jilin University) Li, Yu-Ying (Department of Oncology, the First Hospital of Jilin University) Jin, Chun-Hui (Department of Oncology, the First Hospital of Jilin University) Li, Dan (Department of Oncology, the First Hospital of Jilin University) Bai, Ou (Department of Oncology, the First Hospital of Jilin University)

저널정보: 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제14권 제2호

발행연도: 2013.1

수록면: 959 - 962 (4page)

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Objective: HBV infection may cause damage to the immune system and induce lymphomas as a result. Some scholars have indicated that HBsAg(+) reflecting HBV infection may have a relationship with lymphoma development. This study was designed to find out the specific stage of HBV infection which may be related to lymphoma. Methods: HBV serum markers, including HBsAg, HBsAb, HBeAg, HBeAb, HBcAb were tested among 100 lymphoma patients and 100 other patients who were diagnosed with non-lymphoma diseases in the First Hospital of Jilin University from 2010.1.1 to 2012.12.31. Three subgroups were established depending on different combinations of HBV serum markers. Subgroup 1 was HBsAg(+) representing the early stage of HBV infection. Subgroup 2 was HbsAb(+) representing convalescence and Subgroup 3 was "HbsAg and HbsAb negative combined with other positive markers" representing the intermediate stage of HBV infection. Chi square tests were used to compare the rates of three subgroups in lymphoma and control groups. Results: The rates of Subgroup were 13% and 5% respectively, an association between HBsAg and lymphoma being found (P<0.05). There was no difference between rate of Subgroup 2 of lymphoma group (15%) and that of control group (16%). In lymphoma group and control group, the rate of Subgroup 3 was different (12% vs 4%). This evidence was not specific to T cell lymphoma, B cell lymphoma or Hodgkin's lymphoma. Conclusions: Among serum markers of HBV, the combination of serum markers representing the early stage and intermediate stage of HBV infection have a relationship with lymphoma. Convalescence from HBV infection appears to have no relationship with lymphoma.

#Lymphoma #hepatitis B virus #serum markers

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