FDG PET-CT in Non-small Cell Lung Cancer: Relationship between Primary Tumor FDG Uptake and Extensional or Metastatic Potential

Zhu, Shou-Hui; Zhang, Yong; Yu, Yong-Hua; Fu, Zheng; Kong, Lei; Han, Da-Li; Fu, Lei; Yu, Jin-Ming; Li, Jia

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저자정보: Zhu, Shou-Hui (Department of Radiation Oncology, Shandong Cancer Hospital and Institute, Shandong Academy of Medical Sciences) Zhang, Yong (Department of Radiation Oncology, Shandong Cancer Hospital and Institute, Shandong Academy of Medical Sciences) Yu, Yong-Hua (Department of Radiation Oncology, Shandong Cancer Hospital and Institute, Shandong Academy of Medical Sciences) Fu, Zheng (Department of Positron Emission Tomography/Computed Tomography, Shandong Cancer Hospital and Institute, Shandong Academy of Medical Sciences) Kong, Lei (Department of Radiation Oncology, Shandong Cancer Hospital and Institute, Shandong Academy of Medical Sciences) Han, Da-Li (Department of Radiation Oncology, Shandong Cancer Hospital and Institute, Shandong Academy of Medical Sciences) Fu, Lei (Department of Radiation Oncology, Shandong Cancer Hospital and Institute, Shandong Academy of Medical Sciences) Yu, Jin-Ming (Department of Radiation Oncology, Shandong Cancer Hospital and Institute, Shandong Academy of Medical Sciences) Li, Jia (Department of Radiation Oncology, Shandong Cancer Hospital and Ins)

저널정보: 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제14권 제5호

발행연도: 2013.1

수록면: 2,925 - 2,929 (5page)

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Objective: To explore the relationships between primary tumor $^{18}F$-FDG uptake measured as the SUVmax and local extension, and nodal or distant organ metastasis in patients with NSCLC on pretreatment PET-CT. Methods: 93 patients with NSCLC who underwent $^{18}F$-FDG PET-CT scans before the treatment were included in the study. Primary tumor SUVmax was calculated; clinical stages, presence of local extension, nodal and distant organ metastases were recorded. The patients with SUVmax${\geq}2.5$ were divided into low and high SUVmax groups by using the median SUVmax. The low SUVmax group consisted of 45 patients with SUVmax<10.5, the high SUVmax group consisted of 46 patients with SUVmax${\geq}10.5$. Their data were compared statistically. Results: 91 cases with SUVmax${\geq}2.5$ were included for analysis. The mean SUVmax in patients without any metastasis was $7.42{\pm}2.91$ and this was significantly lower than that ($12.18{\pm}4.94$) in patients with nodal and/or distant organ metastasis (P=0.000). In the low SUV group, 19 patients had local extension, 22 had nodal metastasis, and 9 had distant organ metastasis. In the high SUV group, 31 patients had local extension, 37 had nodal metastasis, and 18 had distant organ metastases. There was a significant difference in local extension (P =0.016), distant organ metastasis (P =0.046), and most significant difference in nodal metastasis rate (P =0.002) between the two groups. In addition, there was a moderate correlation between SUVmax and tumor size (r = 0.642, P<0.001), tumor stage (r = 0.546, P<0.001), node stage (r = 0.388, P<0.001), and overall stage (r = 0.445, P= 0.000). Conclusion: Higher primary tumor SUVmax predicts higher extensional or metastatic potential in patients with NSCLC. Patients with higher SUVmax may need a close follow-up and more reasonable individual treatment because of their higher extensional and metastatic potential.

#Non-small cell lung cancer #FDG-PET #SUV #clinical staging #metastasis

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Zhu, Shou-Hui

소속기관 Department of Radiation Oncology, Shandong Cancer Hospital and Institute, Shandong Academy of Medica