Association of XRCC1 Gene Polymorphisms with Breast Cancer Susceptibility in Saudi Patients

Al Mutairi, Fatima Masoud; Alanazi, Mohammed; Shalaby, Manal; Alabdulkarim, Huda A.; Pathan, Akbar Ali Khan; Parine, Narasimha Reddy

추천

검색

자료유형: 학술저널

저자정보: Al Mutairi, Fatima Masoud (Genome Research Chair, Department of Biochemistry, College of Science, King Saud University) Alanazi, Mohammed (Genome Research Chair, Department of Biochemistry, College of Science, King Saud University) Shalaby, Manal (Genome Research Chair, Department of Biochemistry, College of Science, King Saud University) Alabdulkarim, Huda A. (The Comprehensive Cancer Center at King Fahad Medical City) Pathan, Akbar Ali Khan (Genome Research Chair, Department of Biochemistry, College of Science, King Saud University) Parine, Narasimha Reddy (Genome Research Chair, Department of Biochemistry, College of Science, King Saud University)

저널정보: 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제14권 제6호

발행연도: 2013.1

수록면: 3,809 - 3,813 (5page)

이용수

📌

연구주제

📖

연구배경

🔬

연구방법

🏆

연구결과

초록· 키워드

오류제보하기

Background: X-ray repair cross-complementing group 1 (XRCC1) plays a key role in the base excision repair pathway, as a scaffold protein that brings together proteins of the DNA repair complex. XRCC1 is reported to be a candidate influence on cancer risk. The aim of our present study was to assess the association of rs1799782 (Arg194Trp) and rs25487 (Arg399Gln) XRCC1 gene polymorphisms with breast cancer in the Saudi population. Materials and Methods: The two SNP's were analyzed in breast cancer patients and healthy control subjects. Genotypes were determined by TaqMan SNP genotype analysis technique and data were analyzed using Chi-square or t test and logistic regression analysis by SPSS16.0 software. Results and Conclusions: Results showed that rs1799782 significantly increased susceptibility to breast cancer with Arg/Trp, Arg/Trp+Trp/Trp genotypes and at Trp allele overall study. It also increased risk of breast cancer in older age patients (above 48) and with the ER positive category. XRCC1rs25487 (Arg399Gln) did not showed any significant association. In conclusion the XRCC1rs1799782 polymorphism may be involved in the etiology of breast cancer in the Saudi population. Confirmation of our findings in larger populations of different ethnicities is warranted.

#XRCC1 #Saudi population #breast cancer #genetic polymorphism

참고문헌 (0)

참고문헌 신청

참고문헌이 DBpia에서 서비스 중이라면, [참고문헌 신청]을 통해 등록해보세요

이 논문의 저자 정보

Al Mutairi, Fatima Masoud

소속기관 Genome Research Chair, Department of Biochemistry, College of Science, King Saud University