Serum Tumor Markers, Hypoxia-Inducible factor-1α HIF-1α and Vascular Endothelial Growth Factor, in Patients with Non-small Cell Lung Cancer Before and after Intervention

Liang, Jun; Qian, Ying; Xu, Dan; Yin, Qun; Pan, Hui-Juan

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자료유형: 학술저널

저자정보: Liang, Jun (Department of Oncology, Wuxi People's Hospital of Huishan District) Qian, Ying (Department of Oncology, Wuxi People's Hospital of Huishan District) Xu, Dan (Department of Oncology, Wuxi People's Hospital of Huishan District) Yin, Qun (Nursing Department, Wuxi People's Hospital of Huishan District) Pan, Hui-Juan (Nursing Department, Wuxi People's Hospital of Huishan District)

저널정보: 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제14권 제6호

발행연도: 2013.1

수록면: 3,851 - 3,854 (4page)

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Objective: To explore changes in the serum tumor makers, hypoxia-inducible factor-$1{\alpha}$ (HIF-$1{\alpha}$) and vascular endothelial growth factor (VEGF) level and their relations in patients with non-small cell lung cancer (NSCLC) before and after intervention. Materials and Methods: Forty patients with NSCLC and 40 healthy individuals undergoing physical examination in our hospital provided the observation and control groups. HIF-$1{\alpha}$ and VEGF levels in serum were detected by enzyme-linked immuno-sorbent assay (ELISA) in the observation group before and after intervention and in control group on the day of physical examination, along with serum carcino-embryonic antigen (CEA), neuron-speci ic enolase (NSE) and squamous cell carcinoma antigen (SCC) levels in the observation group with a fully automatic biochemical analyzer. Clinical effects and improvement of life quality in the observation group were also evaluated. Results: The total effective rate and improvement of life quality after treatment in observation group were 30.0% and 32.5%, respectively. Serum HIF-$1{\alpha}$ and VEGF levels in the control group were lower than that in observation group (p<0.01), but remarkably elevatedafter intervention (p<0.01). In addition, serum CEA, NSE and SCC levels were apparently lowered by treatment (p<0.01). Serum HIF-$1{\alpha}$ demonstrated a positive relation with VEGF level (p<0.01) and was inversely related with CEA, NSE and SCC levels (p<0.01). Conclusions: Significant correlations exist between marked increase of serum HIF-$1{\alpha}$ and VEGF levels and decrease of indexes related to hematological tumor markers in NSCLC patients after intervention.

#Intervention #non-small cell lung cancer #vascular endothelial growth factor #hypoxia-inducible factor- $1{alpha}$

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Liang, Jun

소속기관 Department of Medical Research Center, Department of Oncology, the Affiliated Hospital of Qingdao Un