May the Platelet to Lymphocyte Ratio be a Prognostic Factor for Epithelial Ovarian Cancer?

Kokcu, Arif; Kurtoglu, Emel; Celik, Handan; Tosun, Migraci; Malatyalıoglu, Erdal; Ozdemir, Ayse Zehra

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자료유형: 학술저널

저자정보: Kokcu, Arif (Department of Obstetrics and Gynecology, Faculty of Medicine, University of Ondokuz Mayis) Kurtoglu, Emel (Department of Obstetrics and Gynecology, Faculty of Medicine, University of Ondokuz Mayis) Celik, Handan (Department of Obstetrics and Gynecology, Faculty of Medicine, University of Ondokuz Mayis) Tosun, Migraci (Department of Obstetrics and Gynecology, Faculty of Medicine, University of Ondokuz Mayis) Malatyalıoglu, Erdal (Department of Obstetrics and Gynecology, Faculty of Medicine, University of Ondokuz Mayis) Ozdemir, Ayse Zehra (Department of Obstetrics and Gynecology, Faculty of Medicine, University of Ondokuz Mayis)

저널정보: 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제15권 제22호

발행연도: 2014.1

수록면: 9,781 - 9,784 (4page)

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Background: The study aimed to evaluate changes in hematologic parameters, including white blood cell, platelet count, platelet indices, the platelet to lymphocyte and neutrophil to lymphocyte ratios in patients with early and advanced stages of epithelial ovarian cancers. Materials and Methods: The study included 100 patients with epithelial ovarian cancer who underwent primary staging exploratory laparotomy. Preoperative hematologic parameters, tumor histopathologic type, grade, stage and serum CA-125 levels were retrospectively analyzed. These parameters were compared between the patients with early (stage I-II) and advanced (stage III-IV) ovarian cancer. Results: White blood cell count and platelet indices, including mean platelet volume, platelet distribution width and platelet crit did not show a statistically significant difference between groups with early and advanced ovarian cancer. However, the neutrophil to lymphocyte ratio, platelet count, the platelet to lymphocyte ratio and CA-125 level showed a statistically significant difference between the two groups (p<0.05, p<0.01, p<0.001, p<0.01 respectively). Conclusions: It was found that the neutrophil to lymphocyte ratio, platelet count and the platelet to lymphocyte ratio increased with the increasing stage of ovarian cancer. Furthermore, it was seen that the platelet to lymphocyte ratio is an independent prognostic factor related to the stage of epithelial ovarian cancer.

#Epithelial ovarian cancer #neutrophil to lymphocyte ratio #prognostic factor

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