Diagnostic Accuracy of 18F-FDG-PET in Patients with Testicular Cancer: a Meta-analysis

Zhao, Jing-Yi; Ma, Xue-Lei; Li, Yan-Yan; Zhang, Bing-Lan; Li, Min-Min; Ma, Xue-Lei; Liu, Lei

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저자정보: Zhao, Jing-Yi (Cancer Center and State Key Laboratory of Biotherapy, West China Hospital, West China Medical School, Sichuan University) Ma, Xue-Lei (Cancer Center and State Key Laboratory of Biotherapy, West China Hospital, West China Medical School, Sichuan University) Li, Yan-Yan (Cancer Center and State Key Laboratory of Biotherapy, West China Hospital, West China Medical School, Sichuan University) Zhang, Bing-Lan (Cancer Center and State Key Laboratory of Biotherapy, West China Hospital, West China Medical School, Sichuan University) Li, Min-Min (Cancer Center and State Key Laboratory of Biotherapy, West China Hospital, West China Medical School, Sichuan University) Ma, Xue-Lei (Cancer Center and State Key Laboratory of Biotherapy, West China Hospital, West China Medical School, Sichuan University) Liu, Lei (Cancer Center and State Key Laboratory of Biotherapy, West China Hospital, West China Medical School, Sichuan University)

저널정보: 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제15권 제8호

발행연도: 2014.1

수록면: 3,525 - 3,531 (7page)

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Objective: Fluorine-18-fluorodeoxyglucose positron emission tomography (18F-FDG-PET) is a new technique for identifying different malignant tumors using different uptake values between tumor cells and normal tissues. Here we assessed the diagnostic accuracy of 18F-FDG-PET in patients with testicular cancer by pooling data of existing trials in a meta-analysis. Methods: PubMed/MEDLINE, Embase and Cochrane Central Trials databases were searched and studies published in English relating to the diagnostic value of FDG-PET for testicular cancer were collected. The summary receiver operating characteristic (SROC) curve was used to examine the FDG-PET accuracy. Results: A total of 16 studies which included 957 examinations in 807 patients (median age, 31.1 years) were analyzed. A meta-analysis was performed to combine the sensitivity and specificity and their 95% confidence intervals (CIs), from diagnostic odds ratio (DOR), positive likelihood ratios (PLR), negative likelihood ratio (NLR). SROC were derived to demonstrate the diagnostic accuracy of FDG-PET for testicular cancer. The pooled sensitivity and specificity were 0.75 (95% confidence interval (CI), 0.70-0.80) and 0.87 (95% CI, 0.84-0.89), respectively. The pooled DOR was 35.6 (95% CI, 12.9-98.3). The area under the curve (AUC) was 0.88. The pooled PLR and pooled NLR were 7.80 (95% CI, 3.73-16.3) and 0.31 (95% CI, 0.23-0.43), respectively. Conclusion: In patients with testicular cancer, 18F-FDG-PET demonstrated a high SROC area, and could be a potentially useful tool if combined with other imaging methods such as MRI and CT. Nevertheless, the literature focusing on the use of 18F-FDG-PET in this setting still remains limited.

#$^{18}F$-FDG-PET #testicular cancer #diagnosis #meta-analysis

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Zhao, Jing-Yi

소속기관 Cancer Center and State Key Laboratory of Biotherapy, West China Hospital, West China Medical School