Lack of Association Between CYP1A1 Polymorphisms and Risk of Bladder Cancer: a Meta-analysis

Lu, Yu; Zhang, Xiao-Lian; Xie, Li; Li, Tai-Jie; He, Yu; Peng, Qi-Liu; Deng, Yan; Wang, Jian; Qin, Xue; Li, Shan

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자료유형: 학술저널

저자정보: Lu, Yu (Department of Clinical Laboratory, First Affiliated Hospital of Guangxi Medical University) Zhang, Xiao-Lian (Department of Clinical Laboratory, First Affiliated Hospital of Guangxi Medical University) Xie, Li (Department of Clinical Laboratory, First Affiliated Hospital of Guangxi Medical University) Li, Tai-Jie (Department of Clinical Laboratory, First Affiliated Hospital of Guangxi Medical University) He, Yu (Department of Clinical Laboratory, First Affiliated Hospital of Guangxi Medical University) Peng, Qi-Liu (Department of Clinical Laboratory, First Affiliated Hospital of Guangxi Medical University) Deng, Yan (Department of Clinical Laboratory, First Affiliated Hospital of Guangxi Medical University) Wang, Jian (Department of Clinical Laboratory, First Affiliated Hospital of Guangxi Medical University) Qin, Xue (Department of Clinical Laboratory, First Affiliated Hospital of Guangxi Medical University) Li, Shan (Department of Clinical Laboratory, First Affiliated Hospital of Guangxi Medical University)

저널정보: 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제15권 제9호

발행연도: 2014.1

수록면: 4,071 - 4,077 (7page)

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Background: The effects of CYP1A1 gene polymorphisms on the risk of bladder cancer (BC) remain controversial. We carried out a meta-analysis to clarify the role of CYP1A1 gene polymorphisms in BC. Material and Methods: A comprehensive literature search was conducted up to November 20, 2013. Odds ratios (ORs) with 95% confidence intervals (CIs) were used to estimate the strength of the association. Meta-regression, subgroup analysis, sensitivity analysis and publication bias were also performed. Results: Eight studies involving 1,059 BC cases and 1,061 controls were included. The meta-analysis showed that there was no significant association between the two common mutations of CYP1A1 and BC risk. For the I1e462Val A/G polymorphism with GG vs. AA the OR was 1.47 (95 % CI= 0.70-3.07, P =0.308). For the MspI T/C polymorphism, though a slight trend was found this was not statistically nonsignificant (CC vs.TT, OR = 1.24, 95 % CI= 0.98-1.58, P =0.078). Subgroup analyses by ethnicity also found no obvious association between CYP1A1 and BC risk. Conclusion: The present meta-analysis suggests that CYP1A1 polymorphism is not associated with bladder cancer risk.

#Bladder cancer #CYP1A1 #I1e462Val #mspI #polymorphisms #meta-analysis

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