Genetic Variants at 6p21.1 and 7p15.3 Identified by GWASs of Multiple Cancers and Ovarian Cancer Risk: a Case-control Study in Han Chinese Women

Li, Da-Ke; Han, Jing; Liu, Ji-Bin; Jin, Guang-Fu; Qu, Jun-Wei; Zhu, Meng; Wang, Yan-Ru; Jiang, Jie; Ma, Hong-Xia

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저자정보: Li, Da-Ke (Department of Gynaecology, Jiangsu Provincial Hospital of TCM, Affliated hospital of Nanjing University of TCM) Han, Jing (MOE Key Laboratory of Modern Toxicology, School of Public Health, Nanjing Medical University) Liu, Ji-Bin (Nantong Tumor Hospital) Jin, Guang-Fu (Jiangsu Key Laboratory of Cancer Biomarkers, Prevention and Treatment, Nanjing Medical University) Qu, Jun-Wei (Jiangsu Province Tumor Hospital Department of Gynaecology) Zhu, Meng (MOE Key Laboratory of Modern Toxicology, School of Public Health, Nanjing Medical University) Wang, Yan-Ru (MOE Key Laboratory of Modern Toxicology, School of Public Health, Nanjing Medical University) Jiang, Jie (MOE Key Laboratory of Modern Toxicology, School of Public Health, Nanjing Medical University) Ma, Hong-Xia (MOE Key Laboratory of Modern Toxicology, School of Public Health, Nanjing Medical University)

저널정보: 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제15권 제1호

발행연도: 2014.1

수록면: 123 - 127 (5page)

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A recent study summarized several published genome-wide association studies (GWASs) of cancer and reported two pleiotropic loci at 6p21.1 and 7p15.3 contributing to multiple cancers including lung cancer, noncardia gastric cancer (NCGC), and esophageal squamous-cell carcinoma (ESCC) in Han Chinese. However, it is not known whether such genetic variants have similar effects on the risk of gynecologic cancers, such as ovarian cancer. Hence, we explored associations between genetic variants in 6p21.1 and 7p15.3 and ovarian cancer risk in Han Chinese women. We performed an independent case-control study by genotyping the two loci (rs2494938 A > G at 6p21.1 and rs2285947 A > G at 7p15.3) in a total of 377 ovarian cancer cases and 1,034 cancer-free controls using TaqMan allelic discrimination assay. We found that rs2285947 at 7p15.3 was significantly associated with risk of ovarian cancer with per allele odds ratio (OR) of 1.33 [95% confidence interval (CI): 1.08-1.64, P=0.008]. However, no significant association was observed between rs2494938 and ovarian cancer risk. Our results showed that rs2285947 at 7p15.3 may also contribute to the development of ovarian cancer in Han Chinese women, further suggesting pleiotropy of 7p15.3 in multiple cancers.

#Ovarian cancer #Chinese women #GWASs #single nucleotide polymorphism #7p15 #3

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Li, Da-Ke

소속기관 Department of Gynaecology, Jiangsu Provincial Hospital of TCM, Affliated hospital of Nanjing Univers