Prognostic Value of Peritoneal Washing Cytology in Gynecologic Malignancies: a Controversial Issue

Binesh, Fariba; Akhavan, Ali; Behniafard, Nasim; Zabihi, Somayeh; Hosseinizadeh, Elhamsadat

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저자정보: Binesh, Fariba (Department Of Pathology, Shahid Sadoughi University Of Medical Sciences) Akhavan, Ali (Department Of Radiotherapy, Isfahan University Of Medical Sciences) Behniafard, Nasim (General Practitioner) Zabihi, Somayeh (Department Of Pathology, Shahid Sadoughi University Of Medical Sciences) Hosseinizadeh, Elhamsadat (General Practitioner)

저널정보: 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제15권 제21호

발행연도: 2014.1

수록면: 9,405 - 9,410 (6page)

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Purpose: To evaluate the prognostic impact of peritoneal washing cytology in patients with endometrial and ovarian cancers. Materials and Methods: We retrospectively identified 86 individuals with ovarian carcinomas, ovarian borderline tumors and endometrial adenocarcinomas. The patients had been treated at Shahid Sadoughi Hospital and Ramazanzadeh Radiotherapy Center, Yazd, Iran between 2004 and 2012. Survival differences were determined by Kaplan-Meier analysis. Multivariate analysis was performed using the Cox regression method. A p<0.05 value was considered statistically significant. Results: There were 36 patients with ovarian carcinomas, 4 with borderline ovarian tumors and 46 with endometrial carcinomas. The mean age of the patients was $53.8{\pm}15.2years$. In patients with ovarian carcinoma the overall survival in the negative cytology group was better than the patients with positive cytology although this difference failed to reach statistical significance (p=0.30). At 0 to 50 months the overall survival was better in patients with endometrial adenocarcinoma and negative cytology than the patients with positive cytology but then it decreased (p=0.85). At 15 to 60 months patients with FIGO 2009 stage IA-II endometrial andocarcinoma and negative peritoneal cytology had a superior survival rate compared to 1988 IIIA and positive cytology only, although this difference failed to reach statistical significance(p=0.94). Multivariate analysis using Cox proportional hazards model showed that stage and peritoneal cytology were predictors of death. Conclusions: Our results show good correlation of peritoneal cytology with prognosis in patients with ovarian carcinoma. In endometrial carcinoma it had prognostic importance. Additional research is warranted.

#Peritoneal washing cytology #endometrial cancer #ovarian cancer #survival #gynecology

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