Benefit of Post-mastectomy Radiotherapy of the Supra-/infraclavicular Lymphatic Drainage Area in Breast Cancer Patients

He, Zhen-Yu; Wu, San-Gang; Zhou, Juan; Sun, Jia-Yuan; Li, Feng-Yan; Lin, Qin; Guo, Ling; Lin, Huan-Xin

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자료유형: 학술저널

저자정보: He, Zhen-Yu (Department of Radiation Oncology, State Key Laboratory of Oncology in Southern China, Sun Yat-Sen University Cancer Center) Wu, San-Gang (Department of Radiation Oncology, Xiamen Cancer Center, the First Affiliated Hospital of Xiamen University) Zhou, Juan (Department of Obstetrics and Gynecology, the First Affiliated Hospital of Xiamen University) Sun, Jia-Yuan (Department of Radiation Oncology, State Key Laboratory of Oncology in Southern China, Sun Yat-Sen University Cancer Center) Li, Feng-Yan (Department of Radiation Oncology, State Key Laboratory of Oncology in Southern China, Sun Yat-Sen University Cancer Center) Lin, Qin (Department of Radiation Oncology, Xiamen Cancer Center, the First Affiliated Hospital of Xiamen University) Guo, Ling (Department of Nasopharyngeal Carcinoma, State Key Laboratory of Oncology in Southern China, Sun Yat-Sen University Cancer Center) Lin, Huan-Xin (Department of Radiation Oncology, State Key Laboratory of Oncology in Southern China, Sun Yat-Sen University Cancer Center)

저널정보: 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제15권 제14호

발행연도: 2014.1

수록면: 5,557 - 5,563 (7page)

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Background: This study investigated the survival benefit of radiotherapy (RT) of the supra- and infraclavicular lymphatic drainage area in Chinese women with T1-2N1M0 breast cancer receiving mastectomy. Methods: A total of 593 cases were retrospectively reviewed from 1998 to 2007. The relationship between supra- or infraclavicular fossa relapse (SCFR) and post-operative RT at the supra-/infraclavicular lymphatic drainage area was evaluated. Results: The majority of patients (532/593; 89. 8%) received no RT while 61 patients received RT. The median follow-up was 85 months. Among patients without RT, 54 (10. 2%) developed recurrence in the chest wall or ipsilateral SCFR. However, none of the 61 patients who underwent RT demonstrated SCFR. One patient who received RT (1. 6%) experienced recurrence in the chest wall. Univariate analysis revealed that age and molecular subtype (both P < 0. 05) were two prognostic factors related to supraclavicular and infraclavicular fossa relapse-free survival (SFRFS). Multivariate analysis revealed that only Her-2 positive status (P = 0. 011) was an independent predictor of SFRFS. RT had no influence on distant metastasis (P = 0. 328) or overall survival (P = 0. 541). SCFR significantly affected probability of distant metastasis (P < 0. 001) and overall survival (P < 0. 001). Conclusion: Although RT was not significantly associated with SFRFS, postoperative RT was significantly associated with a lower locoregional (i. e., supraclavicular/infraclavicular and chest wall) recurrence rate. SCFR significantly influenced distant metastasis-free survival, which significantly influenced the overall survival of T1-2N1M0 breast cancer patients after mastectomy. Thus, prophylactic RT is recommended in T1-2N1M0 breast cancer patients, especially those who have Her-2 positive lesions.

#Axillary lymph nodes #breast cancer #radiotherapy #relapse-free survival #distant metastasis-free survival

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He, Zhen-Yu

소속기관 Department of Radiation Oncology, State Key Laboratory of Oncology in Southern China, Sun Yat-Sen Un