Impact of Prognostic Factors on Survival Rates in Patients with Ovarian Carcinoma

Arikan, Sevim Kalsen; Kasap, Burcu; Yetimalar, Hakan; Yildiz, Askin; Sakarya, Derya Kilic; Tatar, Sumeyra

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자료유형: 학술저널

저자정보: Arikan, Sevim Kalsen (Obstetrics and Gynecology, Ataturk Training and Research Hospital) Kasap, Burcu (Obstetrics and Gynecology, Faculty of Medicine, Mugla Sitki Kocman University) Yetimalar, Hakan (Obstetrics and Gynecology, Ataturk Training and Research Hospital) Yildiz, Askin (Obstetrics and Gynecology, Ataturk Training and Research Hospital) Sakarya, Derya Kilic (Obstetrics and Gynecology, Ataturk Training and Research Hospital) Tatar, Sumeyra (Obstetrics and Gynecology, Faculty of Medicine, Sifa University)

저널정보: 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제15권 제15호

발행연도: 2014.1

수록면: 6,087 - 6,094 (8page)

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Purpose: The aim of the present study was to invesitigate the impact of significant clinico-pathological prognostic factors on survival rates and to identify factors predictive of poor outcome in patients with ovarian carcinoma. Materials and Methods: A retrospective chart review of 74 women with pathologically proven ovarian carcinoma who were treated between January 2006 and April 2011 was performed. Patients were investigated with respect to survival to find the possible effects of age, gravida, parity, menstruel condition, pre-operative Ca-125, treatment period, cytologic washings, presence of ascites, tumor histology, stage and grade, maximal tumor diameter, adjuvan chemotherapy and cytoreductive success. Also 55 ovarian carcinoma patients were investigated with respect to prognostic factors for early 2-year survival. Results: The two-year survival rate was 69% and the 5-year survival rate was 25.5% for the whole study population. Significant factors for 2-year survival were preoperative CA-125 level, malignant cytology and FIGO clinical stage. Significant factors for 5-year survival were age, preoperative CA-125 level, residual tumor, lymph node metastases, histologic type of tumor, malignant cytology and FIGO clinical stage. Logistic regression revealed that independent prognostic factors of 5-year survival were patient age, lymph node metastasis and malignant cytology. Conclusions: We consider quality registries with prospectively collected data to be one important tool in monitoring treatment effects in population-based cancer research.

#Ovarian cancer #prognostic factors #survival analysis #Turkey

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