Association of Leptin Receptor Lys109Arg and Gln223Arg Polymorphisms with Increased Risk of Clear Cell Renal Cell Carcinoma

Mu, Hui-Jun; Zou, Jian; Xie, Ping; Xu, Zhuo-Qun; Ruan, Jun; Yang, Shu-Dong; Yin, Ying

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자료유형: 학술저널

저자정보: Mu, Hui-Jun (Department of Clinical Laboratory Science, Wuxi People's Hospital of Nanjing Medical University) Zou, Jian (Department of Clinical Laboratory Science, Wuxi People's Hospital of Nanjing Medical University) Xie, Ping (Department of Clinical Laboratory Science, Wuxi People's Hospital of Nanjing Medical University) Xu, Zhuo-Qun (Department of Urinary Surgery, Wuxi People's Hospital of Nanjing Medical University) Ruan, Jun (Department of Urinary Surgery, Wuxi People's Hospital of Nanjing Medical University) Yang, Shu-Dong (Department of Pathology, Wuxi People's Hospital of Nanjing Medical University) Yin, Ying (Department of Clinical Laboratory Science, Wuxi People's Hospital of Nanjing Medical University)

저널정보: 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제15권 제10호

발행연도: 2014.1

수록면: 4,211 - 4,215 (5page)

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Background: Although roles of genetic polymorphisms of leptin receptor (LEPR) gene in several cancers have been documented, the association between polymorphisms of LEPR and clear cell renal cell carcinoma (CC-RCC) remains unknown. The aim of this study was to explore any relation. Materials and Methods: The study population consisted of 77 patients with CC-RCC and 161 healthy control subjects. Polymorphism analyses of Lys109Arg and Gln223Arg were performed by direct DNA sequencing and PCR-restriction fragment length polymorphism approaches respectively. Results: Comparisons of allelic and genotypic frequencies in Lys109Arg and Gln223Arg showed no significant difference between the cases and controls. However, when evaluating the combined genotype of Lys109Arg and Gln223Arg, risk with GG/GG was increased (OR=1.85, 95%CI=1.04-3.30) and with GA/GG or GG/GA was decreased (OR=0.07, 95%CI=0.01-0.54; OR and 95%CI of the latter could not be calculated for a value of zero). Furthermore, the G-G haplotype frequency of Lys109Arg and Gln223Arg in the cases was higher (OR=1.68; 95%CI=1.02-2.76). In contrast, the A-G and G-A haplotype frequencies in the cases were lower than those in the controls (OR=0.06; 95%CI=0.01 to 0.47; OR and 95%CI of the latter could not be calculated for a value of zero). In addition, the Lys109Arg A allele was in LD with the Gln223Arg A allele (d'=0.9399) in the CC-RCC subjects, but not in the controls. Conclusions: Our data suggest that the GG/GG combined genotype and G-G haplotype of Lys109Arg and Gln223Arg can act as evaluating factors for CC-RCC risk.

#Leptin receptor #polymorphism #clear cell renal cell carcinoma

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Mu, Hui-Jun

소속기관 Department of Clinical Laboratory Science, Wuxi People's Hospital of Nanjing Medical University